2026-04-17T04:33:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4558612026-03-13T07:35:22Zcom_2072_98col_2072_378192

Single-layer graphene modulates neuronal communication and augments membrane ion currents Pampaloni, Niccolò Paolo Lottner, Martin Giugliano, Michele Matruglio, Alessia D'Amico, Francesco Prato, Maurizio Garrido, Jose Ballerini, Laura Scaini, Denis Associated functions Biosensing interfaces Cellular changes Central nervous systems Insulating substrates Ion interactions Neuronal firings Theoretical approach Action Potentials Animals Biocompatible Materials Cell Communication Cells, Cultured Graphite Nanostructures Nerve Net Neurons Potassium Rats The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. Graphene's peculiar properties can cause various cellular changes, but the underlying mechanisms remain unclear. Here, we show that single-layer graphene increases neuronal firing by altering membrane-associated functions in cultured cells. Graphene tunes the distribution of extracellular ions at the interface with neurons, a key regulator of neuronal excitability. The resulting biophysical changes in the membrane include stronger potassium ion currents, with a shift in the fraction of neuronal firing phenotypes from adapting to tonically firing. By using experimental and theoretical approaches, we hypothesize that the graphene-ion interactions that are maximized when single-layer graphene is deposited on electrically insulating substrates are crucial to these effects. 2018 Article European Commission 720270 European Commission 696656 Agencia Estatal de Investigación CTQ2016-76721-R Nature Nanotechnology ; Vol. 13 Núm. 8 (August 2018), p. 755-764 open access Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets. https://rightsstatements.org/vocab/InC/1.0/