2026-04-13T03:04:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4556962025-07-29T19:22:29Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Zacarías-Fluck, Mariano F. author Jauset González, Toni author Martínez-Martín, Sandra author Kaur, Jastrinjan author Casacuberta-Serra, Sílvia author Massó Vallés, Daniel author Serrano del Pozo, Erika author Martín-Fernández, Génesis author González-Larreategui, Íñigo author López-Estévez, Sergio author Brown-Swigart, Lamorna author Beaulieu, Marie-Eve author Whitfield, Jonathan R. author Madan, Babita author Virshup, David M. author Evan, Gerard I author Soucek, Laura author 2021 Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas. The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets