2026-04-13T05:53:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4556962025-07-29T19:22:29Zcom_2072_98col_2072_378192

urn:hdl:2072/455696 The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets Zacarías-Fluck, Mariano F. Jauset González, Toni Martínez-Martín, Sandra Kaur, Jastrinjan Casacuberta-Serra, Sílvia Massó Vallés, Daniel Serrano del Pozo, Erika Martín-Fernández, Génesis González-Larreategui, Íñigo López-Estévez, Sergio Brown-Swigart, Lamorna Beaulieu, Marie-Eve Whitfield, Jonathan R. Madan, Babita Virshup, David M. Evan, Gerard I Soucek, Laura Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas. The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. 2021 Article Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-3193 Ministerio de Economía y Competitividad IJCI-2014-22403 Agència de Gestió d'Ajuts Universitaris i de Recerca 2016FI_B00592 Life Science Alliance ; Vol. 4 (march 2021) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/