2026-04-17T20:40:15Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4556622024-11-01T00:07:03Zcom_2072_98col_2072_378192

COVID-19 : A Therapeutic Approach Based on Pathophysiological Staging Domingo, Christian Universitat Autònoma de Barcelona. Departament de Medicina COVID-19 SARS-CoV-2 The COVID-19 pandemic is a recently emerging problem. This has caused that the knowledge of the disease has been progressive and, therefore, the therapeutic decisions have been conditioned by this lack of knowledge on the one hand and by the therapeutic limitations on the other. Many published studies are methodologically weak and their conclusions, of limited value, have contributed to creating confusion on the therapeutic approach of the disease. In the present paper, we propose a therapeutic approach based on a new disease staging. The therapeutic approach is divided into two big sections: the pharmacological treatment for the phase of viral replication, cytokine storm or late respiratory events (which includes the adult respiratory distress syndrome (ARDS)) and the treatment of the respiratory failure In every stage, we discuss the pathophysiology and comment (accept or rule out) the pharmacological options according to the present evidence. Moreover, we indicate how respiratory failure should be treated. Some characteristics are based on the evidence found in the literature. Others are the result of my experience in other situations. 2020 Article https://ddd.uab.cat/record/238682 urn:10.2174/1874306402014010032 urn:oai:ddd.uab.cat:238682 urn:pmcid:PMC7705954 urn:pmc-uid:7705954 urn:pmid:33299490 urn:articleid:18743064v14p32 urn:oai:pubmedcentral.nih.gov:7705954 urn:oai:egreta.uab.cat:publications/71ecdd86-184e-4366-a731-f8a29e7da4c2 urn:scopus_id:85097886901 urn:oai:egreta.uab.cat:publications/71ecdd86-184e-4366-a731-f8a29e7da4c2 http://hdl.handle.net/2072/455662 eng The Open Respiratory Medicine Journal ; Vol. 14 (october 2020), p. 32-37 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf