2026-04-13T01:57:59Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4556082026-03-13T07:31:30Zcom_2072_98col_2072_378192

Differences in breast cancer risk after benign breast disease by type of screening diagnosis Louro, Javier Román, Marta Posso, Margarita Comerma, Laura Vidal, Carmen Saladié, Francina Alcántara Souza, Rodrigo Sanchez, Mar Quintana Ruiz, Maria Jesús del Riego, Javier Ferrer, Joana Peñalva, Lupe Bargalló, Xavier Prieto, Miguel Sala, Maria Castells, Xavier Universitat Autònoma de Barcelona Breast neoplasms Early cancer detection Benign breast disease Risk factors We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively). Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis. 2020 Article Instituto de Salud Carlos III PI15-00098 Instituto de Salud Carlos III PI17-00047 Instituto de Salud Carlos III RD12-0001-0015 Breast ; Vol. 54 (october 2020), p. 343-348 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/