2026-04-18T05:46:36Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4478872024-12-20T21:09:24Zcom_2072_300912com_2072_4427col_2072_301309
RECERCAT author Le Saux, Emilien author Ma, Dengke author Bonilla, Pablo author Holden, Catherine M. author Lustosa, Danilo author Melchiorre, Paolo 2021-04-19T09:58:26Z2024-04-23T10:44:30Z 2021-04-19T09:58:26Z2024-04-23T10:44:30Z 2020-12-07 http://hdl.handle.net/2072/447887 https://doi.org/10.1002/anie.202014876 Herein, we report a general iminium ion‐based catalytic method for the enantioselective conjugate addition of carbon‐centered radicals to aliphatic and aromatic enals. The process uses an organic photoredox catalyst, which absorbs blue light to generate radicals from stable precursors, in combination with a chiral amine catalyst, which secures a consistently high level of stereoselectivity. The generality of this catalytic platform is demonstrated by the stereoselective interception of a wide variety of radicals, including non‐stabilized primary ones which are generally difficult to engage in asymmetric processes. The system also served to develop organocatalytic cascade reactions that combine an iminium‐ion‐based radical trap with an enamine‐mediated step, affording stereochemically dense chiral products in one‐step. eng L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ AGeneral Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion URL https://recercat.cat/bitstream/2072/447887/4/20_A%20General%20Organocatalytic%20System%20for%20Enantioselective%20Radical%20Conjugate%20Additions%20to%20Enals.pdf File MD5 a443faa971f963b85747cbc6d9ffe324 1930462 application/pdf 20_A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals.pdf URL https://recercat.cat/bitstream/2072/447887/5/20_A%20General%20Organocatalytic%20System%20for%20Enantioselective%20Radical%20Conjugate%20Additions%20to%20Enals.pdf.txt File MD5 f65d9e5f6fcd224622444d27cde05210 27676 text/plain 20_A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals.pdf.txt