2026-04-18T05:17:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4478872024-12-20T21:09:24Zcom_2072_300912com_2072_4427col_2072_301309

00925njm 22002777a 4500 dc Le Saux, Emilien author Ma, Dengke author Bonilla, Pablo author Holden, Catherine M. author Lustosa, Danilo author Melchiorre, Paolo author 2020-12-07 Herein, we report a general iminium ion‐based catalytic method for the enantioselective conjugate addition of carbon‐centered radicals to aliphatic and aromatic enals. The process uses an organic photoredox catalyst, which absorbs blue light to generate radicals from stable precursors, in combination with a chiral amine catalyst, which secures a consistently high level of stereoselectivity. The generality of this catalytic platform is demonstrated by the stereoselective interception of a wide variety of radicals, including non‐stabilized primary ones which are generally difficult to engage in asymmetric processes. The system also served to develop organocatalytic cascade reactions that combine an iminium‐ion‐based radical trap with an enamine‐mediated step, affording stereochemically dense chiral products in one‐step. http://hdl.handle.net/2072/447887 https://doi.org/10.1002/anie.202014876 AGeneral Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals