2026-04-13T18:24:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4300892026-03-13T04:56:44Zcom_2072_98col_2072_378192

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy González, Carolina Tabernero, David Cortese, Maria Francesca Gregori i Font, Josep Casillas, Rosario Riveiro Barciela, Mar Godoy, Cristina Sopena, Sara Rando-Segura, Ariadna Yll, Marçal Lopez Martinez, Rosa Quer, Josep Esteban, Rafael Buti, Maria Rodríguez Frías, Francisco Hepatitis B virus Hepatitis B X gene Hepatitis B X protein Gene therapy Next-generation sequencing HBV conserved regions Small interference RNA To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia. 2018 Article Ministerio de Economía y Competitividad PI15/00856 World Journal of Gastroenterology ; Vol. 24 (may 2018), p. 2095-2107 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by-nc/4.0/