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oai:recercat.cat:2072/3739392024-12-20T22:20:29Zcom_2072_300912com_2072_4427col_2072_301309

Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible-Light Photoredox Catalysis Claros, Miguel Ungeheuer, Felix Franco, Federico Martin-Diaconescu, Vlad Casitas, Alicia Lloret-Fillol, Julio 54 The chemical inertness of abundant and commercially available alkyl chlorides precludes their widespread use as reactants in chemical transformations. Presented in this work is a metallaphotoredox methodology to achieve the catalytic intramolecular reductive cyclization of unactivated alkyl chlorides with tethered alkenes. The cleavage of strong C(sp3)@Cl bonds is mediated by a highly nucleophilic lowvalent cobalt or nickel intermediate generated by visible-light photoredox reduction employing a copper photosensitizer. The high basicity and multidentate nature of the ligands are key to obtaining efficient metal catalysts for the functionalization of unactivated alkyl chlorides. 2019-02-01 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/2072/373939 https://doi.org/10.1002/anie.201812702 eng ERC-CG-2014-648304 CTQ2016- 80038-R L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess 4869 p. application/pdf RECERCAT (Dipòsit de la Recerca de Catalunya)