2026-04-17T06:34:30Zhttps://recercat.cat/oai/requestoai:recercat.cat:2072/3685572024-12-20T18:54:01Zcom_2072_300912com_2072_4427col_2072_301309
2020-01-21T11:56:44Z
urn:hdl:2072/368557
Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups
Tan, Eric
Quinonero, Ophélie
de Orbe, M. Elena
Echavarren, Antonio M.
We report the alkynylation of C(sp2)−H bonds
with bromoalkynes (inverse-Sonogashira reaction) directed by
synthetically useful ester, ketone, and ether groups under
rhodium catalysis. Other less common directing groups such as
amine, thioether, sulfoxide, sulfone, phenol ester, and
carbamate are also suitable directing groups. Mechanistic
studies indicate that the reaction proceeds by a turnoverlimiting
C−H activation step via an electrophilic-type
substitution.
2020-01-21T11:56:44Z
2024-04-23T10:19:02Z
2020-01-21T11:56:44Z
2024-04-23T10:19:02Z
2018-01-29
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://hdl.handle.net/2072/368557
https://doi.org/10.1021/acscatal.7b04395
eng
CTQ2016- 75960-P MINECO/AEI/FEDER, UE
SEV-2013-0319
Advanced Grant No. 321066
2014 SGR 818
info:eu-repo/semantics/openAccess
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RECERCAT (Dipòsit de la Recerca de Catalunya)