2026-04-17T01:19:34Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/3575282024-12-20T22:33:41Zcom_2072_300912com_2072_4427col_2072_301309

A visible-light mediated three-component radical process using dithiocarbamate anion catalysis Cuadros, Sara Horwitz, Matthew A. Schweitzer-Chaput, Bertrand Melchiorre, Paolo We report a photoinduced three-component radical process, which couples readily available alkyl chlorides, maleimides, and heteroaromatic fragments to rapidly generate complex chiral products with high diastereocontrol. This method generates radicals via an SN2-based photochemical catalytic mechanism, which is not reliant on the redox properties of the precursors. It therefore grants access to open-shell intermediates from substrates that would be incompatible with or inert to classical radical- generating strategies. The redox-neutral conditions of this process make it tolerant of redox-sensitive substrates and allow the installation of multiple biologically relevant heterocycles within the cascade products. 2019-06-17T12:20:20Z 2024-04-23T10:19:15Z 2019-06-17T12:20:20Z 2024-04-23T10:19:15Z 2019-06-17T12:20:20Z 2024-04-23T10:19:15Z 2019-02-18 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/2072/357528 https://doi.org/10.1039/c9sc00833k eng info:eu-repo/grantAgreement/EC/FP7/681840 info:eu-repo/semantics/openAccess L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ RECERCAT (Dipòsit de la Recerca de Catalunya)