2026-04-14T05:08:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/3506942024-12-20T17:18:00Zcom_2072_300912com_2072_4427col_2072_301309

00925njm 22002777a 4500 dc Mazzarella, Daniele author Crisenza, Giacomo E. M. author Melchiorre, Paolo author 2018-06-22 Reported herein is a visible-light-mediated organocatalytic direct C−H functionalization of toluene derivatives to afford enantioenriched β-benzylated alde- hydes from the corresponding enals. The process combines the oxidative power of a chiral excited-state iminium ion and the basic nature of its counteranion to trigger the generation of benzylic radicals by means of a sequential multisite proton-coupled electron transfer mechanism. This study shows that feedstock chemicals generally used as solvents, such as toluene and xylene derivatives, can be used as substrates for making chiral molecules with high enantioselectivity. http://hdl.handle.net/2072/350694 https://doi.org/10.1021/jacs.8b05240 Asymmetric Photocatalytic C−H Functionalization of Toluene and Derivatives