2026-04-14T04:32:14Zhttps://recercat.cat/oai/requestoai:recercat.cat:2072/3506882024-12-20T17:36:45Zcom_2072_300912com_2072_4427col_2072_301309
RECERCAT
author
Filippini, Gicomo
author
Silvi, Mattia
author
Melchiorre, Paolo
2019-02-27T15:43:45Z2024-04-23T10:21:03Z
2019-02-27T15:43:45Z2024-04-23T10:21:03Z
2017-03-21
http://hdl.handle.net/2072/350688
https://doi.org/10.1002/anie.201612045
Detailed herein is the photochemical organocatalytic enantioselective a-alkylation of aldehydes with (phenylsulfo- nyl)alkyl iodides. The chemistry relies on the direct photo- excitation of enamines to trigger the formation of reactive carbon-centered radicals from iodosulfones, while the ground- state chiral enamines provide effective stereochemical control over the radical trapping process. The phenylsulfonyl moiety, acting as a redox auxiliary group, facilitates the generation of radicals. In addition, it can eventually be removed under mild reducing conditions to reveal methyl and benzyl groups.
eng
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Enantioselective Formal a-Methylation and a-Benzylation of Aldehydes by Means of Photo-organocatalysis
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URL
https://recercat.cat/bitstream/2072/350688/5/17_Enantioselective%20Formal%20%ce%b1-Benzylation%20of%20Aldehydes%20by%20Means%20of%20Photo-Organocatalysis.pdf
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17_Enantioselective Formal α-Benzylation of Aldehydes by Means of Photo-Organocatalysis.pdf
URL
https://recercat.cat/bitstream/2072/350688/1/17_Enantioselective%20Formal%20%ce%b1-Benzylation%20of%20Aldehydes%20by%20Means%20of%20Photo-Organocatalysis.pdf.txt
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17_Enantioselective Formal α-Benzylation of Aldehydes by Means of Photo-Organocatalysis.pdf.txt