2026-04-13T16:53:16Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/3059242026-01-15T14:12:33Zcom_2072_300912com_2072_4427col_2072_301309
00925njm 22002777a 4500 dc Wu, Yichen author Izquierdo, Susana author Vidossich, Pietro author Lledos, Agustí author Shafir, Alexandr author 2016 <p> <span lang="EN-US" style="margin: 0px; color: rgb(0, 0, 170); font-family: &quot;Cambria&quot;,serif; font-size: 12pt;">The synthesis of N-arylimidazoles substituted at the sterically encumbered 5-position is a challenge for modern synthetic approaches. A new family of imidazolyl aryliodonium salts is reported, which serve as a stepping stone on the way to selective formation of N1-aryl-5-iodoimidazoles. Iodine acts as a &ldquo;universal&rdquo; placeholder poised for replacement by aryl substituents. These new &lambda;<sup>3</sup>-iodanes are produced by treating the NH-imidazole with ArI(OAc)<sub>2</sub>, and are converted to N1-aryl-5-iodoimidazoles by a selective copper-catalyzed aryl migration. The method tolerates a variety of aryl fragments and is also applicable to substituted imidazoles.</span></p> http://hdl.handle.net/2072/305924 https://doi.org/10.1002/anie.201602569 NH-Heterocyclic Aryliodonium Salts and their Selective Conversion into N1-Aryl-5-iodoimidazoles