2026-04-13T02:22:52Zhttps://recercat.cat/oai/request
oai:recercat.cat:20.500.14342/7592025-05-15T19:19:09Zcom_2072_482405com_2072_183628col_2072_482409
RECERCAT author Hernáez, Álvaro author Soria Florido, María Trinidad author Schröder, Helmut author Ros Rahola, Emilio author Pintó Sala, Xavier author Estruch Riba, Ramon author Salas Salvadó, Jordi author Corella Piquer, Dolores author Arós, Fernando author Serra Majem, Lluís author Martínez-González, Miguel Ángel, 1957- author Fiol Sala, Miguel author Lapetra, José author Elosua Llanos, Roberto author Lamuela Raventós, Rosa Ma. author Fitó Colomer, Montserrat 2025-05-15T19:19:09Z 2025-05-15T19:19:09Z 2019-06 http://hdl.handle.net/20.500.14342/759 https://dx.doi.org/10.1371/journal.pone.0218533 Background High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity. eng Attribution 4.0 International © L'autor/a Sistema cardiovascular -- Malalties -- Factors de risc Lipoproteïnes de densitat alta Lipoproteïnes de densitat baixa Colesterol Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion