2026-04-14T07:11:13Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/52712025-05-24T19:14:44Zcom_2072_482405com_2072_183628col_2072_482409
Intensive weight-loss lifestyle intervention using Mediterranean diet and COVID-19 risk in older adults: secondary analysis of PREDIMED-Plus Trial
Shyam, S.
García-Gavilán, Jesús
Paz Graniel, Indira
Gaforio, Jose J
Martínez-González, Miguel Ángel
Corella Piquer, Dolores
Martínez, José Alfredo
Alonso Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López Miranda, José
Estruch Riba, Ramon
Tinahones Madueño, Francisco J.
Lapetra, José
Serra Majem, Lluís
Bueno-Cavanillas, Aurora
Tur, Josep A.
Martín Sánchez, Vicente
Pintó Sala, Xavier
Matía Martín, Pilar
Vidal, Josep
Alcarria, M. del Mar
Daimiel, Lidia
Ros Rahola, Emilio
Fernández-Aranda, Fernando
Nishi, Stephanie K.
García Regata, Óscar
Pérez-Araluce, Rafael
Asensio, Eva Maria
Castañer, Olga
Garcia-Rios, Antonio
Oncina Canovas, Alejandro
Bouzas, Cristina
Zulet, M. Angeles
Rayó Gago, Elena
Casas, Rosa
Martin-Pelaez, S.
Tojal Sierra, Lucas
Bernal-López, M. Rosa
Carlos, Silvia
Sorlí, José V.
Goday, Alberto
Peña Orihuela, Patricia J
Pastor-Morel, A.
Eguaras, Sonia
Zomeño, M. Dolores
Delgado-Rodríguez, Miguel
Babio, Nancy
Fitó Colomer, Montserrat
Salas Salvadó, Jordi
Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
COVID-19 (Malaltia)
SARS-CoV-2 (Malaltia)
PREDIMED-Plus
Dieta mediterrània
Persones grans
Objectives
We tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.
Design
Secondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.
Setting
Community-dwelling, free-living participants in PREDIMED-Plus trial.
Participants
6,874 Spanish older adults (55–75 years, 49% women) with overweight/obesity and metabolic syndrome.
Intervention
Participants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.
Measurements
COVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.
Results
Overall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).
Conclusions
There was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.
info:eu-repo/semantics/publishedVersion
2023-12
info:eu-repo/semantics/article
http://hdl.handle.net/20.500.14342/5271
https://doi.org/10.1007/s12603-023-2044-4
eng
The Journal of nutrition, health and aging, 2023, 27(12): 1162-1167
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6 p.
Elsevier