2026-04-17T15:53:43Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/52712025-05-24T19:14:44Zcom_2072_482405com_2072_183628col_2072_482409
RECERCAT
author
Shyam, S.
author
García-Gavilán, Jesús
author
Paz Graniel, Indira
author
Gaforio, Jose J
author
Martínez-González, Miguel Ángel
author
Corella Piquer, Dolores
author
Martínez, José Alfredo
author
Alonso Gómez, Ángel M.
author
Wärnberg, Julia
author
Vioque, Jesús
author
Romaguera, Dora
author
López Miranda, José
author
Estruch Riba, Ramon
author
Tinahones Madueño, Francisco J.
author
Lapetra, José
author
Serra Majem, Lluís
author
Bueno-Cavanillas, Aurora
author
Tur, Josep A.
author
Martín Sánchez, Vicente
author
Pintó Sala, Xavier
author
Matía Martín, Pilar
author
Vidal, Josep
author
Alcarria, M. del Mar
author
Daimiel, Lidia
author
Ros Rahola, Emilio
author
Fernández-Aranda, Fernando
author
Nishi, Stephanie K.
author
García Regata, Óscar
author
Pérez-Araluce, Rafael
author
Asensio, Eva Maria
author
Castañer, Olga
author
Garcia-Rios, Antonio
author
Oncina Canovas, Alejandro
author
Bouzas, Cristina
author
Zulet, M. Angeles
author
Rayó Gago, Elena
author
Casas, Rosa
author
Martin-Pelaez, S.
author
Tojal Sierra, Lucas
author
Bernal-López, M. Rosa
author
Carlos, Silvia
author
Sorlí, José V.
author
Goday, Alberto
author
Peña Orihuela, Patricia J
author
Pastor-Morel, A.
author
Eguaras, Sonia
author
Zomeño, M. Dolores
author
Delgado-Rodríguez, Miguel
author
Babio, Nancy
author
Fitó Colomer, Montserrat
author
Salas Salvadó, Jordi
2025-05-24T19:14:44Z
2025-05-24T19:14:44Z
2023-12
http://hdl.handle.net/20.500.14342/5271
https://doi.org/10.1007/s12603-023-2044-4
Objectives
We tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.
Design
Secondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.
Setting
Community-dwelling, free-living participants in PREDIMED-Plus trial.
Participants
6,874 Spanish older adults (55–75 years, 49% women) with overweight/obesity and metabolic syndrome.
Intervention
Participants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.
Measurements
COVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.
Results
Overall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).
Conclusions
There was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.
eng
© SERDI Publisher Attribution-NonCommercial-NoDerivatives 4.0 International
COVID-19 (Malaltia)
SARS-CoV-2 (Malaltia)
PREDIMED-Plus
Dieta mediterrània
Persones grans
Intensive weight-loss lifestyle intervention using Mediterranean diet and COVID-19 risk in older adults: secondary analysis of PREDIMED-Plus Trial
info:eu-repo/semantics/article