2026-04-19T16:18:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/52712025-05-24T19:14:44Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Shyam, S. author García-Gavilán, Jesús author Paz Graniel, Indira author Gaforio, Jose J author Martínez-González, Miguel Ángel author Corella Piquer, Dolores author Martínez, José Alfredo author Alonso Gómez, Ángel M. author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López Miranda, José author Estruch Riba, Ramon author Tinahones Madueño, Francisco J. author Lapetra, José author Serra Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A. author Martín Sánchez, Vicente author Pintó Sala, Xavier author Matía Martín, Pilar author Vidal, Josep author Alcarria, M. del Mar author Daimiel, Lidia author Ros Rahola, Emilio author Fernández-Aranda, Fernando author Nishi, Stephanie K. author García Regata, Óscar author Pérez-Araluce, Rafael author Asensio, Eva Maria author Castañer, Olga author Garcia-Rios, Antonio author Oncina Canovas, Alejandro author Bouzas, Cristina author Zulet, M. Angeles author Rayó Gago, Elena author Casas, Rosa author Martin-Pelaez, S. author Tojal Sierra, Lucas author Bernal-López, M. Rosa author Carlos, Silvia author Sorlí, José V. author Goday, Alberto author Peña Orihuela, Patricia J author Pastor-Morel, A. author Eguaras, Sonia author Zomeño, M. Dolores author Delgado-Rodríguez, Miguel author Babio, Nancy author Fitó Colomer, Montserrat author Salas Salvadó, Jordi author 2023-12 Objectives We tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults. Design Secondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial. Setting Community-dwelling, free-living participants in PREDIMED-Plus trial. Participants 6,874 Spanish older adults (55–75 years, 49% women) with overweight/obesity and metabolic syndrome. Intervention Participants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations. Measurements COVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk. Results Overall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)). Conclusions There was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks. http://hdl.handle.net/20.500.14342/5271 https://doi.org/10.1007/s12603-023-2044-4 COVID-19 (Malaltia) SARS-CoV-2 (Malaltia) PREDIMED-Plus Dieta mediterrània Persones grans Intensive weight-loss lifestyle intervention using Mediterranean diet and COVID-19 risk in older adults: secondary analysis of PREDIMED-Plus Trial