2026-04-14T06:01:24Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/52702025-05-24T19:14:41Zcom_2072_482405com_2072_183628col_2072_482409
2025-05-24T19:14:41Z
urn:hdl:20.500.14342/5270
Increased ultra-processed food consumption is associated with worsening of cardiometabolic risk factors in adults with metabolic syndrome: Longitudinal analysis from a randomized trial
González Palacios, Sandra
Oncina Canovas, Alejandro
Garcia de la Hera, Manuela
Martínez-González, Miguel Ángel
Salas Salvadó, Jordi
Corella Piquer, Dolores
Schröder, Helmut
Martínez, José Alfredo
Alonso Gómez, Ángel M.
Wärnberg, Julia
Romaguera, Dora
López Miranda, José
Estruch Riba, Ramon
Tinahones Madueño, Francisco J.
Lapetra, José
Serra Majem, Lluís
Cano-Ibáñez, Naomi
Tur, Josep A.
Martín Sánchez, Vicente
Pintó Sala, Xavier
Delgado-Rodríguez, Miguel
Matía Martín, Pilar
Vidal, Josep
Vázquez, Clotilde
Daimiel, Lidia
Ros, Emilio
Bes-Rastrollo, Maira
Atzeni, Alessandro
Sorli, Jose V.
Zomeño, M. Dolores
Peña Orihuela, Patricia J
Compañ-Gabucio, Laura
Barón López, Francisco Javier
Zulet, M. Angeles
Konieczna, Jadwiga
Casas, Rosa
Garrido-Garrido, Eva
Tojal Sierra, Lucas
Gómez-Pérez, Ana Maria
Ruiz-Canela, Miguel
Palau Galindo, Antoni
Saiz, Carmen
Pérez-Vega, Karla Alejandra
García Rios, Antonio
Torres-Collado, Laura
Basterra-Gortari, Francisco Javier
Garcidueñas Fimbres, Tany Elizabeth
Malcampo, Mireia
Vioque, Jesús
Aliments processats
Sistema cardiovascular -- Malalties
Factors de risc
Síndrome metabòlica
Índex de masa corporal
Pressió sanguínia
Glucèmia
Background and aims
The association between changes in ultra-processed food (UPF) consumption and cardiometabolic risk (CMR) factors remains understudied. We evaluated the association between changes in UPF consumption over 12 months of follow-up and changes in CMR factors in adults diagnosed with metabolic syndrome.
Methods
We analysed data from 5373 adults (aged 55–75 years) participating in the PREDIMED-Plus trial. Diet was evaluated at baseline, 6- and 12-month visits using a validated food frequency questionnaire, and UPF consumption (in grams/day and percentage of total daily dietary intake in grams) was categorized based on NOVA classification. We used mixed-effects linear models with repeated measurements at baseline, 6 and 12 months of follow-up to assess the associations between changes in UPF consumption and changes in CMR factors adjusting for sociodemographic and lifestyles variables.
Results
In multivariable-adjusted models, when comparing the highest versus the lowest quartile of UPF consumption, positive associations were found for several CMR factors: weight (kg, β = 1.09; 95% confidence interval 0.91 to 1.26); BMI (kg/m2, β = 0.39; 0.33 to 0.46); waist circumference (cm, β = 1.03; 0.81 to 1.26); diastolic blood pressure (mm Hg, β = 0.67; 0.29 to 1.06); fasting blood glucose (mg/dl, β = 1.66; 0.61 to 2.70); HbA1c (%, β = 0.04; 0.01 to 0.07); triglycerides (mg/dl, β = 6.79; 3.66 to 9.91) and triglycerides and glucose index (β = 0.06; 0.04 to 0.08).
Conclusions
Higher UPF consumption was associated with adverse evolution in objectively measured CMR factors after 12 months of follow-up in adults with metabolic syndrome. Further research is needed to explore whether these changes persist for longer periods.
2025-05-24T19:14:41Z
2025-05-24T19:14:41Z
2023-02
2023-07
info:eu-repo/semantics/article
http://hdl.handle.net/20.500.14342/5270
https://doi.org/10.1016/j.atherosclerosis.2023.05.022
eng
Atherosclerosis, 2023, 377: 12-23
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Elsevier