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oai:recercat.cat:20.500.14342/52692025-05-24T19:14:34Zcom_2072_482405com_2072_183628col_2072_482409

Association of adiposity and its changes over time with COVID‑19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED‑Plus cohort Shyam, Sangeetha García-Gavilán, Jesús Paz Graniel, Indira Gaforio, Jose J Martínez-González, Miguel Ángel Corella Piquer, Dolores Martínez, José Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch Riba, Ramon Tinahones Madueño, Francisco J. Lapetra, José Serra Majem, Lluís Bueno-Cavanillas, Aurora Tur, Josep A. Martín Sánchez, Vicente Pintó Sala, Xavier Matía Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Fernández-Aranda, Fernando Nishi, Stephanie K. Garcia‑Regata, Oscar Toledo, Estefanía Asensio, Eva Maria Castañer, Olga Garcia-Rios, Antonio Torres-Collado, Laura Gómez-Gracia, Enrique Zulet, M. Angeles Goñi, Nuria Casas, Rosa Cano-Ibáñez, Naomi Tojal Sierra, Lucas Gómez-Pérez, Ana Maria Sorlí, José V. Cinza-Sanjurjo, Sergio Martín‑Peláez, Sandra Peña Orihuela, Patricia J Oncina Canovas, Alejandro Pérez-Araluce, Rafael Zomeño, M. Dolores Chaplin, Alice Delgado-Rodríguez, Miguel Babio, Nancy Fitó Colomer, Montserrat Salas Salvadó, Jordi Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna Obesitat COVID-19 (Malaltia) Persones grans Aprimament Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. info:eu-repo/semantics/publishedVersion 2023-10 info:eu-repo/semantics/article http://hdl.handle.net/20.500.14342/5269 https://doi.org/10.1186/s12916-023-03079-z eng BMC Medicine, 2023, 21: 390 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00673 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00492 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00272 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/01123 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00462 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00233 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/02184 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/00728 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/01090 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI13/01056 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/01722 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00636 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00618 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00696 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/01206 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/01919 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00853 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/01374 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00972 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/00728 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI14/01471 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00473 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00662 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/01873 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/01094 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00501 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00533 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00381 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/00366 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/01522 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI16/01120 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00764 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/01183 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00855 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/01347 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00525 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/01827 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00532 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00215 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/01441 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00508 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/01732 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI17/00926 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00957 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00386 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00309 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/01032 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00576 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00017 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/01226 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/00781 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/01560 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI19/01332 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/01802 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/00138 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/01532 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/00456 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/00339 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/00557 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/00886 info:eu-repo/grantAgreement/MINECO/ISCIII i CIBEROBN/PI20/01158 © L'autor/a Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 13 p. 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