2026-04-18T04:35:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/52692025-05-24T19:14:34Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Shyam, Sangeetha author García-Gavilán, Jesús author Paz Graniel, Indira author Gaforio, Jose J author Martínez-González, Miguel Ángel author Corella Piquer, Dolores author Martínez, José Alfredo author Alonso Gómez, Ángel M. author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López Miranda, José author Estruch Riba, Ramon author Tinahones Madueño, Francisco J. author Lapetra, José author Serra Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A. author Martín Sánchez, Vicente author Pintó Sala, Xavier author Matía Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Fernández-Aranda, Fernando author Nishi, Stephanie K. author Garcia‑Regata, Oscar author Toledo, Estefanía author Asensio, Eva Maria author Castañer, Olga author Garcia-Rios, Antonio author Torres-Collado, Laura author Gómez-Gracia, Enrique author Zulet, M. Angeles author Goñi, Nuria author Casas, Rosa author Cano-Ibáñez, Naomi author Tojal Sierra, Lucas author Gómez-Pérez, Ana Maria author Sorlí, José V. author Cinza-Sanjurjo, Sergio author Martín‑Peláez, Sandra author Peña Orihuela, Patricia J author Oncina Canovas, Alejandro author Pérez-Araluce, Rafael author Zomeño, M. Dolores author Chaplin, Alice author Delgado-Rodríguez, Miguel author Babio, Nancy author Fitó Colomer, Montserrat author Salas Salvadó, Jordi author 2023-10 Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. http://hdl.handle.net/20.500.14342/5269 https://doi.org/10.1186/s12916-023-03079-z Obesitat COVID-19 (Malaltia) Persones grans Aprimament Association of adiposity and its changes over time with COVID‑19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED‑Plus cohort