2026-04-13T02:24:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/52682025-05-24T19:14:38Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Deschasaux, Mélanie author Huybrechts, Inge author Murphy, Neil author Julia, Chantal author Hercberg, Serge author Srour, Bernard author Kesse-Guyot, Emmanuelle author Latino-Martel, Paule author Biessy, Carine author Casagrande, Corinne author Jenab, Mazda author Ward, Heather A. author Weiderpass, Elisabete author Dahm, Christina C. author Overvad, Kim author Kyrø, Cecilie author Olsen, Anja author Affret, Aurélie author Boutron-Ruault, Marie-Christine author Mahamat-Saleh, Yahya author Kaaks, Rudolf author Kühn, Tilman author Boeing, Heiner author Schwingshackl, Lukas author Bamia, Christina author Peppa, Eleni author Trichopoulou, Antonia author Masala, Giovanna author Krogh, Vittorio author Panico, Salvatore author Tumino, Rosario author Sacerdote, Carlotta author Bueno de Mesquita, H. Bas author Peeters, Petra H. author Hjartåker, Anette author Rylander, Charlotta author Skeie, Guri author Quirós, José Ramón author Jakszyn, Paula author Salamanca-Fernández, Elena author Huerta, José María author Ardanaz, Eva author Amiano, Pilar author Ericson, Ulrika author Sonestedt, Emily author Huseinovic, Ena author Johansson, Ingegerd author Khaw, Kay-Tee author Wareham, Nick author Bradbury, Kathryn E. author Perez-Cornago, Aurora author Tsilidis, Konstantinos K. author Ferrari, Pietro author Riboli, Elio author Gunter, Marc J. author Touvier, Mathilde author 2018-09 Background Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling system to reflect the nutritional quality of food products. The Nutri-Score, a five-colour nutrition label, is derived from the Nutrient Profiling System of the British Food Standards Agency (modified version) (FSAm-NPS). How the consumption of foods with high/low FSAm-NPS relates to cancer risk has been studied in national/regional cohorts but has not been characterized in diverse European populations. Methods and findings This prospective analysis included 471,495 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC, 1992–2014, median follow-up: 15.3 y), among whom there were 49,794 incident cancer cases (main locations: breast, n = 12,063; prostate, n = 6,745; colon-rectum, n = 5,806). Usual food intakes were assessed with standardized country-specific diet assessment methods. The FSAm-NPS was calculated for each food/beverage using their 100-g content in energy, sugar, saturated fatty acid, sodium, fibres, proteins, and fruits/vegetables/legumes/nuts. The FSAm-NPS scores of all food items usually consumed by a participant were averaged to obtain the individual FSAm-NPS Dietary Index (DI) scores. Multi-adjusted Cox proportional hazards models were computed. A higher FSAm-NPS DI score, reflecting a lower nutritional quality of the food consumed, was associated with a higher risk of total cancer (HRQ5 versus Q1 = 1.07; 95% CI 1.03–1.10, P-trend < 0.001). Absolute cancer rates in those with high and low (quintiles 5 and 1) FSAm-NPS DI scores were 81.4 and 69.5 cases/10,000 person-years, respectively. Higher FSAm-NPS DI scores were specifically associated with higher risks of cancers of the colon-rectum, upper aerodigestive tract and stomach, lung for men, and liver and postmenopausal breast for women (all P < 0.05). The main study limitation is that it was based on an observational cohort using self-reported dietary data obtained through a single baseline food frequency questionnaire; thus, exposure misclassification and residual confounding cannot be ruled out. Conclusions In this large multinational European cohort, the consumption of food products with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher risk of cancer. This supports the relevance of the FSAm-NPS as underlying nutrient profiling system for front-of-pack nutrition labels, as well as for other public health nutritional measures. http://hdl.handle.net/20.500.14342/5268 https://doi.org/10.1371/journal.pmed.1002651 Càncer Aliments Alimentació Factors de risc Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study