2026-04-18T07:59:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/52292025-05-18T19:24:43Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Lujan-Barroso, Leila author Margara Escudero, Hernando J author Crous-Bou, Marta author Huerta, José María author Chirlaque, Maria-Dolores author Molina-Montes, Esther author Sánchez, María-José author Guevara, Marcela author Moreno Iribas, Conchi author Amiano, Pilar author Mokoroa, Olatz author Gonzalez-Solares, Sonia author Agudo, Antonio author Quirós, José Ramón author Jakszyn, Paula author 2024-08 Background: Previous studies have shown that meal timing, poor sleep quality, and chronotype may play a relevant role in the development of type 2 diabetes mellitus (T2DM). However, its relationship with macronutrients by eating occasions has not been explored deeply. Objective: Our aim was to estimate the association between chrono-nutrition, sleep quality, chronotype, and the prevalence of T2DM. Methods: This cross-sectional study included a subset of 3465 middle-aged Caucasian adults (2068 women) from the European Prospective Investigation into Cancer and Nutrition (EPIC) Spain cohort study. In the 2017–18 follow-up, we assessed chronotype, sleep quality, diet, and sociodemographic data using validated questionnaires. Further, we used blood samples to determine serum levels of glucose. We defined a case of T2DM when serum glucose concentration was ≥126 mg/dL or when participants self-reported diabetes. Results: A higher prevalence of T2DM was associated with poor sleep quality (ORpoorvsgood = 2.90, 95% CI = 1.30, 6.28). Carbohydrate intake at breakfast was inversely associated with the prevalence of T2DM (OR = 0.75, 95% CI = 0.66, 0.85). Finally, lipid intake at breakfast was associated with a 13% higher prevalence of T2DM (OR = 1.13, 95% CI = 1.01, 1.26) for each 1 standard deviation (1-SD) increase. Conclusions: This study concludes that a higher content of carbohydrates at breakfast is correlated with a reduced prevalence of T2DM, while higher lipids intake at breakfast is associated with a higher prevalence of T2DM. Furthermore, poor sleep quality is a potential factor associated with an elevated prevalence of T2DM. Our results emphasize the need for prospective studies to validate and strengthen these observed associations. http://hdl.handle.net/20.500.14342/5229 https://doi.org/10.3390/ nu16162598 Crononutrició Diabetis tipus 2 Diabetis no-insulinodependent Horari dels àpats Macronutrients EPIC Chrono-nutrition, chrono-type, and the prevalence of type 2 diabetes mellitus in a cross-sectional study from the EuroPean Prospective Investigation into Cancer and Nutrition (EPIC) study