2026-04-14T07:55:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/51632025-05-15T19:19:47Zcom_2072_482405com_2072_183628col_2072_482409

Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis Torres Castro, Rodrigo Gimeno-Santos, Elena Vilaro, Jordi Roqué Figuls, Marta Moisés , Jorge Vasconcello Castillo, Luis Orizaga, Tanya Barberà, Joan Albert Blanco, Isabel Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna Grup de Recerca Global Research on Wellbeing - GRoW Hipertensió pulmonar Exercici Pulmons -- Malalties obstructives Background Pulmonary hypertension (PH) is a frequent complication in patients with COPD. Objective To determine if, in patients with COPD, the presence of PH decreases exercise tolerance. Methods We included studies that analysed exercise tolerance using a cardiopulmonary exercise test (CPET) in patients with COPD with PH (COPD-PH) and without PH (COPD-nonPH). Two independent reviewers analysed the studies, extracted the data and assessed the quality of the evidence. Results Of the 4915 articles initially identified, seven reported 257 patients with COPD-PH and 404 patients with COPD-nonPH. The COPD-PH group showed differences in peak oxygen consumption (V′O2peak), −3.09 mL·kg−1·min−1 (95% CI −4.74 to −1.43, p=0.0003); maximum workload (Wmax), −20.5 W (95% CI −34.4 to −6.5, p=0.004); and oxygen pulse (O2 pulse), −1.24 mL·beat−1 (95% CI −2.40 to −0.09, p=0.03), in comparison to the group with COPD-nonPH. If we excluded studies with lung transplant candidates, the sensitivity analyses showed even bigger differences: V′O2, −4.26 mL·min−1·kg−1 (95% CI −5.50 to −3.02 mL·kg−1·min−1, p<0.00001); Wmax, −26.6 W (95% CI −32.1 to −21.1 W, p<0.00001); and O2 pulse, −2.04 mL·beat−1 (95% CI −2.92 to −1.15 mL·beat−1, p<0.0001). Conclusion Exercise tolerance was significantly lower in patients with COPD-PH than in patients with COPD-nonPH, particularly in nontransplant candidates. info:eu-repo/semantics/publishedVersion 2021-04 info:eu-repo/semantics/article http://hdl.handle.net/20.500.14342/5163 https://doi.org/10.1183/16000617.0321-2020 eng European respiratory review, 2021, 30(160): 200321 © L'autor/a Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess 13 p. European Respiratory Society