2026-04-17T20:01:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/50682025-05-15T19:19:18Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Ribó-Coll, Margarita author Castro-Barquero, Sara author Lassale, Camille author Sacanella Meseguer, Emilio author Ros Rahola, Emilio author Toledo, Estefanía author Sorlí, José V. author Díaz López, Andrés author Lapetra, José author Muñoz-Bravo, Carlos author Arós, Fernando author Fiol, Miquel author Serra Majem, Lluís author Pintó Sala, Xavier author Castañer, Olga author Fernandez-Lazaro, Cesar I. author Portolés, Olga author Babio, Nancy author Estruch Riba, Ramon author Hernáez, Álvaro author 2021-03 Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvención con DIeta MEDiterránea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71–0.80]), antihypertensive (HR: 0.79 [0.75–0.82]), statin (HR: 0.82 [0.78–0.85]), fibrate (HR: 0.78 [0.68–0.89]), antiplatelet (HR: 0.79 [0.75–0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74–0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56–0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180–360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications. http://hdl.handle.net/20.500.14342/5068 https://doi.org/10.3390/ antiox10030397 Dieta mediterrània Exercici Medicaments Glucosa Antihipertensius Estatines (Medicaments cardiovasculars) Fibrats Antiagregants Vitamines K -- Inhibidors Antianginosos Glucòsids cardíacs Mediterranean diet and physical activity decrease the initiation of cardiovascular drug use in high cardiovascular risk individuals: A cohort study