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oai:recercat.cat:20.500.14342/45752025-05-15T19:17:38Zcom_2072_482405com_2072_183628col_2072_482409

Mediterranean diet, energy restriction, physical activity, and atherogenicity of very-low density lipoproteins: findings from two randomized controlled trials Pérez-Vega, Karla Alejandra Castañer, Olga Sanllorente Melenchon, Albert Lassale, Camille Ros Rahola, Emilio Pintó Sala, Xavier Estruch Riba, Ramon Salas Salvadó, Jordi Corella Piquer, Dolores Alonso Gómez, Ángel M. Serra Majem, Lluís Razquin, Cristina Fiol, Miquel Lapetra, José Gómez-Gracia, Enrique Tinahones Madueño, Francisco J. Hernáez, Álvaro Fitó Colomer, Montserrat Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna Dieta mediterrània Dieta baixa en energia Assaigs clínics Triglicèrids Lipoproteïnes de densitat baixa Scope: Some very-low density lipoprotein (VLDL) properties may render themmore pro-atherogenic. We aimed to assess whether a Mediterranean diet(MedDiet) or an energy-reduced MedDiet with increased physical activityimproves them.Methods and results: In a sample of the PREvención con DIeta MEDiterránea(PREDIMED) study, a 1-year intervention with MedDiet with extra-virgin oliveoil (n = 89) or nuts (MedDiet-Nuts; n = 79) is compared with a low-fat diet(n = 90). In the PREDIMED-Plus study, a 1-year intervention withenergy-reduced MedDiet and physical activity (n = 103) is compared with anad libitum MedDiet (n = 101). VLDL levels of apolipoprotein C-I, C-III,triglycerides, and cholesterol; the apolipoprotein E-/C-I ratio; and VLDLex-vivo triglyceride transfer are measured. In PREDIMED participants in bothMedDiet groups combined, VLDL apolipoprotein C-III levels are nominallyreduced (−0.023 SD units, 95% CI −0.44 to −0.014, p = 0.037). VLDLtriglyceride transfer is nominally increased in the MedDiet-Nuts group (+0.39SD units, 95% CI 0.012–0.78, p = 0.045). In PREDIMED-Plus, no inter-groupdifferences are detected.Conclusions: In older adults at high cardiovascular risk, MedDiet isassociated with lower VLDL atherogenicity versus a low-fat diet. Nodifferences are seen after an energy-reduced MedDiet with physical activity. info:eu-repo/semantics/publishedVersion 2023-01 info:eu-repo/semantics/article http://hdl.handle.net/20.500.14342/4575 https://doi.org/10.1002/mnfr.202200338 eng Molecular Nutrition and Food Research, 2023, 67(1): 2200338 info:eu-repo/grantAgreement/MINECO/ISCIII/FI20/00002 info:eu-repo/grantAgreement/MINECO/ISCIII/PI19/00017 info:eu-repo/grantAgreement/MINECO/ISCIII/PI15/00047 info:eu-repo/grantAgreement/MINECO/ISCIII/PI18/00020 info:eu-repo/grantAgreement/MINECO/ISCIII/PI16/00533 info:eu-repo/grantAgreement/MINECO/ISCIII/PI13/00233 info:eu-repo/grantAgreement/MINECO/ISCIII/PI21/00024 info:eu-repo/grantAgreement/MINECO/ISCIII/PI20/00012 info:eu-repo/grantAgreement/MINECO/ISCIII/CP21/00097 © L'autor/a Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess 8 p. Wiley-VCH GmbH