2026-04-13T07:11:39Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/44862025-05-28T11:59:49Zcom_2072_482405com_2072_183628col_2072_482414
RECERCAT
author
Domínguez García, Pol
author
Gibert, Marta
author
Lacorte, Sílvia
author
Gómez-Canela, Cristian
2022-05
1420-3049
http://hdl.handle.net/20.500.14342/4486
https://doi.org/10.3390/molecules27103203
This study reports the consumption data for 132 anticancer drugs in Catalonia (NE Spain) during the period of 2013–2017 and calculates the predicted environmental concentrations (PECs) in wastewater effluents and rivers. This long-term analysis can determine the evolution of drugs present in the environment according to prescriptions and serve as an adequate tool to determine their presence and impact. Data showed that out of 132 compounds prescribed, 77 reached wastewater effluents, which accounted for the most consumed, those excreted in the highest doses, and the least biodegradable. Once diluted in receiving river waters, only mycophenolic acid and hydroxycarbamide had PEC values higher than 10 ng L−1, which is the value set by the European Medicines Agency (EMA) to carry out further risk assessment. It was also observed that compounds present in river water are those that can pose a high risk, given their persistence and capability to bioaccumulate. Therefore, this study shows that the estimation of PEC, together with physico-chemical properties of detected compounds, is a useful tool to determine the long-term presence and fate of this new class of emerging contaminants.
eng
© L'autor/a Attribution 4.0 International
Anticancer drugs
PECs
Wastewater
River water
Fate
Càncer--Tractament
Aigua--Anàlisi
Aigua--Composició
Long-Term Calculation of Predicted Environmental Concentrations to Assess the Risk of Anticancer Drugs in Environmental Waters
info:eu-repo/semantics/article