2026-04-17T11:45:06Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/39662025-05-15T19:20:49Zcom_2072_482405com_2072_183628col_2072_482409

00925njm 22002777a 4500 dc Lampousi, Anna-Maria author Carlsson, Sofia author Edwall Löfvenborg, Josefin author Cabrera-Castro, Natalia author Chirlaque, Maria-Dolores author Fagherazzi, Guy author Franks, Paul W. author Hampe, Christiane author Jakszyn, Paula author Koulman, Albert author Kyrø, Cecilie author Moreno Iribas, Conchi author Nilsson, Peter M. author Panico, Salvatore author Papier, Keren author van der Schouw, Yvonne T. author Schulze, Matthias B. author Weiderpass, Elisabete author Zamora-Ros, Raul author Forouhi, Nita G. author Sharp, Stephen J. author Rolandsson, Olov author Wareham, Nicholas author 2023-06 Aims/hypothesis Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against GAD65 (GAD65Ab) on the incidence of adult-onset diabetes. Methods We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onset diabetes cases and a subcohort of 14,866 randomly selected individuals. Adjusted Prentice-weighted Cox regression estimated HRs and 95% CIs of diabetes in relation to 1 SD lower plasma phospholipid 15:0 and/or 17:0 concentrations or their main contributor, dairy intake, among GAD65Ab-negative and -positive individuals. Interactions between tertiles of OCFA and GAD65Ab status were estimated by proportion attributable to interaction (AP). Results Low concentrations of OCFA, particularly 17:0, were associated with a higher incidence of adult-onset diabetes in both GAD65Ab-negative (HR 1.55 [95% CI 1.48, 1.64]) and GAD65Ab-positive (HR 1.69 [95% CI 1.34, 2.13]) individuals. The combination of low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity conferred an HR of 7.51 (95% CI 4.83, 11.69), with evidence of additive interaction (AP 0.25 [95% CI 0.05, 0.45]). Low dairy intake was not associated with diabetes incidence in either GAD65Ab-negative (HR 0.98 [95% CI 0.94, 1.02]) or GAD65Ab-positive individuals (HR 0.97 [95% CI 0.79, 1.18]). Conclusions/interpretation Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab positivity to adult-onset diabetes. http://hdl.handle.net/20.500.14342/3966 https://doi.org/10.1007/s00125-023-05948-x Diabetis GAD65Ab Àcid heptadecanoic Autoimmunitat OCFA Àcid pentadecanoic Interaction between plasma phospholipid odd‑chain fatty acids and GAD65 autoantibodies on the incidence of adult‑onset diabetes: the EPIC‑InterAct case–cohort study