2026-04-17T17:14:52Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/39662025-05-15T19:20:49Zcom_2072_482405com_2072_183628col_2072_482409
2025-05-15T19:20:49Z
urn:hdl:20.500.14342/3966
Interaction between plasma phospholipid odd‑chain fatty acids and GAD65 autoantibodies on the incidence of adult‑onset diabetes: the EPIC‑InterAct case–cohort study
Lampousi, Anna-Maria
Carlsson, Sofia
Edwall Löfvenborg, Josefin
Cabrera-Castro, Natalia
Chirlaque, Maria-Dolores
Fagherazzi, Guy
Franks, Paul W.
Hampe, Christiane
Jakszyn, Paula
Koulman, Albert
Kyrø, Cecilie
Moreno Iribas, Conchi
Nilsson, Peter M.
Panico, Salvatore
Papier, Keren
van der Schouw, Yvonne T.
Schulze, Matthias B.
Weiderpass, Elisabete
Zamora-Ros, Raul
Forouhi, Nita G.
Sharp, Stephen J.
Rolandsson, Olov
Wareham, Nicholas
Diabetis
GAD65Ab
Àcid heptadecanoic
Autoimmunitat
OCFA
Àcid pentadecanoic
Aims/hypothesis Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain
fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against
GAD65 (GAD65Ab) on the incidence of adult-onset diabetes.
Methods We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onset diabetes cases and
a subcohort of 14,866 randomly selected individuals. Adjusted Prentice-weighted Cox regression estimated HRs and 95%
CIs of diabetes in relation to 1 SD lower plasma phospholipid 15:0 and/or 17:0 concentrations or their main contributor,
dairy intake, among GAD65Ab-negative and -positive individuals. Interactions between tertiles of OCFA and GAD65Ab
status were estimated by proportion attributable to interaction (AP).
Results Low concentrations of OCFA, particularly 17:0, were associated with a higher incidence of adult-onset diabetes in
both GAD65Ab-negative (HR 1.55 [95% CI 1.48, 1.64]) and GAD65Ab-positive (HR 1.69 [95% CI 1.34, 2.13]) individuals. The combination of low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity conferred an HR
of 7.51 (95% CI 4.83, 11.69), with evidence of additive interaction (AP 0.25 [95% CI 0.05, 0.45]). Low dairy intake was
not associated with diabetes incidence in either GAD65Ab-negative (HR 0.98 [95% CI 0.94, 1.02]) or GAD65Ab-positive
individuals (HR 0.97 [95% CI 0.79, 1.18]).
Conclusions/interpretation Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab
positivity to adult-onset diabetes.
2025-05-15T19:20:49Z
2025-05-15T19:20:49Z
2023-03
2023-06
info:eu-repo/semantics/article
http://hdl.handle.net/20.500.14342/3966
https://doi.org/10.1007/s00125-023-05948-x
eng
Diabetologia, 2023, 66: 1460-1471
info:eu-repo/grantAgreement/EU/H2020/LSHM_CT_2006_037197
info:eu-repo/grantAgreement/NIH/DK-26190 (CSH)
info:eu-repo/grantAgreement/NIH/DK-26190 (CSH)
info:eu-repo/grantAgreement/Västerbotten County Council, UU i MRC/ MC_UU_12015/1 (NJW)
info:eu-repo/grantAgreement/SRCH/FORTE 2018-00337
info:eu-repo/grantAgreement/NNF/NNF19OC0057274
info:eu-repo/grantAgreement/SRC/2018- 03035
info:eu-repo/grantAgreement/SDF/DIA2022-735
info:eu-repo/grantAgreement/MINECO/ISCIII i ESF/CPII20/00009
info:eu-repo/grantAgreement/MIER i GCDR/82DZD03D03
info:eu-repo/grantAgreement/MRC Epidemiology Unit/MC_UU_00006/1
info:eu-repo/grantAgreement/MRC Epidemiology Unit/MC_UU_00006/3
info:eu-repo/grantAgreement/NIH i CBRC/NIHR203312
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
© L'autor/a
Attribution 4.0 International
Springer Nature