2026-04-17T07:00:47Zhttps://recercat.cat/oai/request
oai:recercat.cat:20.500.14342/39552025-05-15T19:21:05Zcom_2072_482405com_2072_183628col_2072_482409
RECERCAT author Prats Uribe, Albert author Sayols Baixeras, Sergi author Fernández Sanlés, Alba author Subirana, Isaac author Carreras-Torres, Robert author Vilahur, Gemma author Civeira, Fernando author Marrugat, Jaume author Fitó Colomer, Montserrat author Hernáez, Álvaro author Elosua Llanos, Roberto 2025-05-15T19:21:05Z 2025-05-15T19:21:05Z 2020-09 http://hdl.handle.net/20.500.14342/3955 https://doi.org/10.1016/j.metabol.2020.154351 Background To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods We designed a two-sample multivariate Mendelian randomization study with available genome-wide association summary data. We identified genetic variants associated with HDL cholesterol and apolipoprotein A-I levels, HDL size, particle levels, and lipid content to define our genetic instrumental variables in one sample (Kettunen et al. study, n = 24,925) and analyzed their association with CAD risk in a different study (CARDIoGRAMplusC4D, n = 184,305). We validated these results by defining our genetic variables in another database (METSIM, n = 8372) and studied their relationship with CAD in the CARDIoGRAMplusC4D dataset. To estimate the effect size of the associations of interest adjusted for other lipoprotein traits and minimize potential pleiotropy, we used the Multi-trait-based Conditional & Joint analysis. Results Genetically determined HDL cholesterol and apolipoprotein A-I levels were not associated with CAD. HDL mean diameter (β = 0.27 [95%CI = 0.19; 0.35]), cholesterol levels in very large HDLs (β = 0.29 [95%CI = 0.17; 0.40]), and triglyceride content in very large HDLs (β = 0.14 [95%CI = 0.040; 0.25]) were directly associated with CAD risk, whereas the cholesterol content in medium-sized HDLs (β = −0.076 [95%CI = -0.10; −0.052]) was inversely related to this risk. These results were validated in the METSIM-CARDIoGRAMplusC4D data. Conclusions Some qualitative HDL characteristics (related to size, particle distribution, and cholesterol and triglyceride content) are related to CAD risk while HDL cholesterol levels are not. eng © Elsevier. Tots els drets reservats Lipoproteïnes de densitat alta Sistema cardiovascular -- Malalties Variables aleatòries Aleatorització Mendeliana Malalties coronàries High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study info:eu-repo/semantics/article