2026-04-17T14:48:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/38972025-05-15T19:19:35Zcom_2072_482405com_2072_183628col_2072_482409

Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study Iglesias Vázquez, Lucía Arija, Victoria Aranda, Núria Aglago, Elom K Cross, Amanda J. Schulze, Matthias B. Quintana Pacheco, Daniel Kühn, Tilman Weiderpass, Elisabete Tumino, Rosario Redondo‑Sánchez, Daniel Santucci de Magistris, Maria Palli, Domenico Ardanaz, Eva Laouali, Nasser Sonestedt, Emily Drake, Isabel Rizzolo-Brime, Lucía Santiuste, Carmen Sacerdote, Carlotta Quirós, José Ramón Amiano, Pilar Agudo, Antonio Jakszyn, Paula Ferritina Ferro en l'organisme Excès de ferro EPIC Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case–control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic infammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was signifcantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex diferences even after excluding participants with hsCRP>5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities. 2025-05-15T19:19:35Z 2025-05-15T19:19:35Z 2025-05-15T19:19:35Z 2021-07 info:eu-repo/semantics/article http://hdl.handle.net/20.500.14342/3897 https://doi.org/10.1007/s00394-021-02625-w eng European Journal of Nutrition, 2022, 61: 101-114 info:eu-repo/grantAgreement/MINECO/ISCIII/PI11/1486 info:eu-repo/semantics/openAccess © Springer Nature. Tots els drets reservats Springer Nature