2026-04-13T01:01:21Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.14342/36842025-05-21T23:40:06Zcom_2072_482405com_2072_183628col_2072_482411
RECERCAT
author
Oviedo, Guillermo R.
author
Carbó-Carreté, Maria
author
Guerra-Balic, Myriam
author
Tamulevicius, Nauris
author
Esquius, Laura
author
Guàrdia Olmos, Joan
author
Javierre, Casimiro
2022-08
http://hdl.handle.net/20.500.14342/3684
https://doi.org/10.3389/fphys.2022.905795
Introduction: The genetic disorder causing Down syndrome (DS) affects the
cardiorespiratory and hemodynamic parameters. When exercising, sufficient
blood flow is necessary for active muscles. Cardiac output (Q) must be
proportional to the peripheral requirements. In case the stroke volume (SV)
is lower, the heart rate (HR) will increase further in order to maintain an adequate
blood flow in the active territories (HR compensatory response). People with DS
have a lower HR response to maximal exercise. Nevertheless, the response of
the hemodynamic and cardiorespiratory parameters during the submaximal
phases of maximal exercise was not well studied.
Objective: to evaluate cardiorespiratory and hemodynamic parameters 1)
during submaximal and 2) maximal metabolic treadmill test in individuals
with and without DS.
Methods: fifteen adults with DS (age = 27.33 ± 4.98 years old; n = 12 males/
3 females) and 15 adultswithout disabilities, matched by age and sex, participated in
this cross-sectional study. Peak and submaximal cardiorespiratory and
hemodynamic parameters were measured during a treadmill test. Linear mixedeffects
models were used to analyse interactions between the variables. Post-hoc
analyses were employed to assess within and between-group differences.
Results: The DS group showed lower peak values for ventilation (VE), respiratory
exchange ratio (RER), tidal volume (VT), ventilatory equivalent for O2 (VEqO2), endtidal
partial pressure for O2 (PETO2), O2 uptake (VO2) andCO2 production (all p < 0
.050), Q, SV, systolic and diastolic blood pressure (SBP,DBP), andHR (all p < 0 .050).
There were group-by-time interactions (all p < 0 .050) for all ventilatory submaximal values. Significant group and time differences were observed for VE;
RER; respiratory rate (RR); VEqO2; PETO2; VO2, and VT (all p < 0 .050). There were
also group-by-time interactions (all p < 0 .050) and group and time differences for
SBP, mean arterial blood pressure (MAP) and HR (all p < 0.010).
Conclusion: During submaximal exercise, we verified a compensatory response
of HR, and greater VE and VO2 in the individuals with DS. In addition, we were
able to observe that the DS group had a reduced SBP and MAP response to
submaximal exercise. On the other hand, we found that adults with DS have
lower peak hemodynamic and cardiorespiratory values, and a lower cardiac
reserve. Further research is warranted to investigate the effects of these results
on the general health of adults with DS and the impact of long-term exercise
programs on these parameters.
eng
© L'autor/a Attribution 4.0 International
Down, Síndrome de
Pressió sanguínia
Exercici cardiorespiratori
Hemodynamic and cardiorespiratory responses to submaximal and maximal exercise in adults with Down syndrome
info:eu-repo/semantics/article