2026-04-13T02:51:20Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.14342/11052025-05-23T06:08:43Zcom_2072_482405com_2072_183628col_2072_482414

00925njm 22002777a 4500 dc Martorell López, Jordi author Molins, Jose Javier author Pons, R. author Guala, A. author Rodríguez-Palomares, J.F. author Cajas, J.C. author Dux-Santoy, L. author Teixidó-Tura, G. author Vázquez, M. author Evangelista, A. author 2020-02 Abnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid–structure interaction (FSI) simulations against four-dimensional (4D) flow magnetic resonance imaging (MRI) data; and to assess the capacity of advanced fluid dynamics markers to stratify aneurysm progression risk. Eight Marfan syndrome (MFS) patients, four with stable and four with dilating aneurysms of the proximal aorta, and four healthy controls were studied. FSI and CFD simulations were performed with MRI-derived geometry, inlet velocity field and Young's modulus. Flow displacement, jet angle and maximum velocity evaluated from FSI and CFD simulations were compared to 4D flow MRI data. A dimensionless parameter, the shear stress ratio (SSR), was evaluated from FSI and CFD simulations and assessed as potential correlate of aneurysm progression. FSI simulations successfully matched MRI data regarding descending to ascending aorta flow rates (R2 = 0.92) and pulse wave velocity (R2 = 0.99). Compared to CFD, FSI simulations showed significantly lower percentage errors in ascending and descending aorta in flow displacement (−46% ascending, −41% descending), jet angle (−28% ascending, −50% descending) and maximum velocity (−37% ascending, −34% descending) with respect to 4D flow MRI. FSI- but not CFD-derived SSR differentiated between stable and dilating MFS patients. Fluid dynamic simulations of the thoracic aorta require fluid–solid interaction to properly reproduce complex haemodynamics. FSI- but not CFD-derived SSR could help stratifying MFS patients. http://hdl.handle.net/20.500.14342/1105 https://doi.org/10.1098/rsos.191752 Aneurismes aòrtics Biologia computacional Dinàmica de fluids--Informàtica Interacció fluid-estructura Ascending aorta aneurysm Marfan syndrome Computational fluid dynamics Fluid–structure interaction Shear stress ratio Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients