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urn:hdl:20.500.14342/1058 Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: the baependi heart study Balcells, Mercedes De Oliveira, Camila Maciel Pavani, Jessica Liu, Chunyu De Oliveira Alvim, Rafael Mourao-Junior, Carlos Alberto Krieger, José Eduardo Da Costa Pereira, Alexandre Glucosa Diabetis Cor--Malalties Baependi Heart Study cohort Triglyceride glucose index Triglycerides Glucose Brazil Type 2 diabetes mellitus Considering that the incidence of type 2 diabetes mellitus (T2DM) has been increasing especially in developing countries and becoming a global public health problem, this study aims to evaluate the association between triglyceride glucose index (TyG) – which is a mathematical product of the fasting blood glucose and triglyceride levels – and incident T2DM in an adult sample in the Baependi Heart Study (BHS). The data were from the BHS cohort consisting of two periods: cycle 1 (2005–2006; n = 1712; 119 families) and cycle 2 (2010–2013; n = 3017; 127 families). A total of 1121 individuals (both sexes, 18–100 years) were selected if they were assessed in both cycles and not diagnosed with T2DM at baseline (cycle 1). Our findings showed that a participant’s risk of developing T2DM increased almost 10 times for a one-unit increase in the TyG (odds ratio OR = 10.17, 95% CI, 7.51–13.93). The association when stratified by age was OR = 28.13 [95% CI, 14.03–56.41] for young adults, meaning that the risk of developing T2DM increased more than 28 times for a one-unit increase in the TyG. For the other groups, young middle-aged adults, old middle-aged adults, and seniors, we found OR = 4.84 [95% CI, 2.91–8.06], OR = 28.73 [95% CI, 10.63–77.65, and OR = 9.88 [95% CI, 3.16–30.90], respectively. A higher TyG implies a significant increase in the risk of developing T2DM, which could be an important screening tool to target early lifestyle intervention in Brazil. 2020-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.14342/1058 https://doi.org/10.1016/j.pmedr.2020.101172 eng Preventive medicine reports. Vol.20 (2020), 101172 info:eu-repo/grantAgreement/SUS-PROADI/Hospital Samaritano Society/Grant no. 25000.180.664/2011-35 info:eu-repo/grantAgreement/MEIC/PN I+D/SAF2017-84773-C2-1-R http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International © L'autor/a Elsevier