2026-04-14T02:40:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12328/52682026-03-25T14:01:39Zcom_2072_67741col_2072_484352

2026-03-25T14:01:39Z urn:hdl:20.500.12328/5268 Benefits of a Natural Dietary Supplement for Tinnitus: An Observational Prospective Exploratory Study Cepeda Uceta, Massiel Lladó-Carbó, Estela Mateo Montero, Raidili Villa Jurado, Catalina Virumbrales Cancio, Montserrat Domènech Juan, Iván Tinnitus Quality of life Dietary supplement L-theanine Melatonin Gaba Ginko biloba Minerals B vitamins Calidad de vida Complementos alimenticios L-teanina Melatonina Minerales Vitaminas del grupo B Acufens Qualitat de vida Suplement dietètic Vitamines del grup B Article Open Access 24 March 2026 Benefits of a Natural Dietary Supplement for Tinnitus: An Observational Prospective Exploratory Study Massiel Cepeda Uceta1,* , Estela Lladó-Carbó2 , Raidili Mateo Montero2 , Catalina Villa Jurado2 , Montserrat Virumbrales3 and Iván Domènech Juan1 1 AMiQ-IMO Otorhinolaryngology and Maxillofacial Surgery, C/Josep Maria Lladó 3, 08035 Barcelona, Spain 2 Neurotoc, C/Padilla 327-329, 08025 Barcelona, Spain 3 Department of Medicine, School of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), 08017 Barcelona, Spain * Author to whom correspondence should be addressed. Audiol. Res. 2026, 16(2), 48; https://doi.org/10.3390/audiolres16020048 This article belongs to the Section Hearing Version Notes Order Reprints Academic Editor Roberto Teggi Roberto Teggi Publication History Received: 19 January 2026 Revised: 5 March 2026 Accepted: 17 March 2026 Published: 24 March 2026 Article Figures (2) Improvement in the quality of life (QoL) according to the decrease in tinnitus-related handicap assessed with the Tinnitus Handicap Inventory (THI) at the end of the study (90 days) as compared with baseline.Improvement in the quality of life (QoL) related to decreases in the subscale of anxiety of the Goldberg anxiety and depression scale (GADS) (missed scores at 90 days for 6 patients). Related Articles AUDISTIM® Day/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial Didier Portmann et al. Audiology Research, 10 April 2024 The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial Anna I. Petridou et al. Nutrients, 12 December 2019 The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores Luca Sacchetto et al. Audiology Research, 7 July 2023 Abstract Background/Objectives: The objective of the study was to assess the benefits on quality of life (QoL) of a natural-based dietary supplement in patients with tinnitus. Methods: An observational, prospective and exploratory study was conducted in 30 patients (mean age 50.7 years) diagnosed with tinnitus. The dietary supplement (Otocalm®) contained L-theanine, Gingko biloba, melatonin, GABA, zinc, selenium and vitamins B3, B6 and B12, and was administered for 90 consecutive days. Clinical assessment included tone verbal audiometry, the Tinnitus Handicap Inventory (THI), the Goldberg anxiety and depression scale (GADS), and a 0–10 mm visual analogue scale (VAS) to score the intensity of tinnitus. Results: The mean THI score decreased from 40.8 at baseline to 30.9 at the end of the study (p = 0.012), and the percentage of patients with THI grade 1 (no handicap) increased from 3.3% to 20%. The mean anxiety score decreased from 4.7 to 3.0 (p = 0.006), and the percentage of patients scoring ≥ 4 in the GADS decreased from 63.3% to 33.3%. Changes in VAS scores and verbal tone audiometry were not observed. A decrease in the mean frequency of tinnitus from 2417.4 Hz to 1603.3 Hz (p = 0.519) was found. The product was safe and well-tolerated. Conclusions: The administration of a natural-based dietary supplement composed of L-theanine, Ginkgo biloba, melatonin, GABA, zinc, selenium, and group B vitamins during 90 days in patients with tinnitus was associated with a significant increase in QoL by reducing tinnitus-associated handicap and anxiety. 2026-03-25T14:01:39Z 2026-03-25T14:01:39Z 2026-03-24 info:eu-repo/semantics/article Cepeda Uceta, Massiel; Lladó-Carbó, Estela; Mateo Montero, Raidili[et al.]. Benefits of a Natural Dietary Supplement for Tinnitus: An Observational Prospective Exploratory Study. Audiology Research, 2026, 16(2), 48. Disponible en <https://www.mdpi.com/3803514>. Fecha de acceso: 24 mar. 2026. DOI: 10.3390/audiolres16020048 2039-4349 https://hdl.handle.net/20.500.12328/5268 https://doi.org/10.3390/audiolres16020048 eng Audiology Research 16;2 info:eu-repo/semantics/openAccess © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. MDPI