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A False Allergic Contact Dermatitis? A Review of Earlobe Eczema Beyond Nickel Allergy: Irritant Mechanisms and Psoriatic Diathesis grimalt, ramon Psoriasis Koebner Contact dermatitis Nickel Eczematous psoriasis False contact dermatitis Fenómeno de Koebner Dermatitis de contacto Níquel Psoriasis eccematosa Falsa dermatitis de contacto Dermatitis de contacte Psoriasi eczematosa Dermatitis de contacte falsa 616.5 Background: Dermatitis affecting the earlobe is a highly frequent clinical presentation, predominantly attributed to Allergic Contact Dermatitis (ACD) caused by metallic ions like nickel from earrings. However, a significant subset of patients presents with recurrent eczematous lesions highly suggestive of ACD but with inconclusive or negative patch test results, posing a profound diagnostic and therapeutic dilemma. Objective: This comprehensive review critically evaluates the differential diagnosis of earlobe eczema in the context of negative patch tests. Drawing from a representative case of a 30-yearold female with recurrent earlobe eczema and a strong family history of psoriasis, we explore alternative non-immunological and endogenous mechanisms, specifically Irritant Contact Dermatitis (ICD) and the Koebner Phenomenon on a background of Psoriatic Diathesis. Methods: We performed an extensive review of the current literature focusing on the epidemiology and pathogenesis of metal ACD, non-allergic mechanisms of jewelryinduced dermatitis (ICD), the molecular basis of the Koebner phenomenon, and the clinical overlap between eczema and psoriasis (Eczematous Psoriasis). Results: The localized nature of the inflammation, coupled with the absence of generalized nickel sensitivity, strongly suggests that the mechanical and occlusive trauma from earrings can induce a purely irritant reaction. Crucially, the presence of a familial psoriatic diathesis supports the hypothesis that this local irritation acts as a Koebner phenomenon trigger, leading to an eczematous manifestation of an underlying psoriatic tendency. Conclusions: Not all recurrent eczematous lesions at common contact sites are caused by ACD. Clinicians must adopt an integrated diagnostic approach, factoring in personal and family history alongside patch test results, to differentiate true allergy from ICD and the Koebner phenomenon. This nuanced perspective is vital for providing appropriate counseling (strict jewelry avoidance) and targeted, often steroid-sparing, management (e.g., topical calcineurin inhibitors) for a durable therapeutic outcome. info:eu-repo/semantics/publishedVersion 2026-01-27 info:eu-repo/semantics/article Grimalt, Ramon. A False Allergic Contact Dermatitis? A Review of Earlobe Eczema Beyond Nickel Allergy: Irritant Mechanisms and Psoriatic Diathesis. Allergies, 2026, 6, 4. Disponible en <https://www.mdpi.com/3699270>. Fecha de acceso: 19 mar. 2026. DOI: 10.3390/allergies6010004 2313-5786 http://hdl.handle.net/20.500.12328/5251 https://doi.org/10.3390/allergies6010004 eng Allergies 6;4 © 2026 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. info:eu-repo/semantics/openAccess 8 MDPI