2026-04-14T02:16:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12328/51742026-01-17T00:52:44Zcom_2072_67741col_2072_484352

00925njm 22002777a 4500 dc Paraiso, West Kristian author Palacin Ramos, Carlos author Hossain, Parisa Mishal author Álvarez Gordi, Carla author Guillen Poza, Pablo Adrian author Zagmutt, Sebastián author Quader, Sabina author Rodriguez-Rodriguez, Rosalia author 2025-12-02 For therapeutics to reach the brain, the several administration routes available come with some disadvantages, with the primary biological obstacle being the blood–brain barrier (BBB), which is not easy to penetrate despite the sophisticated technologies which have been developed. In addition, reaching specific brain structures invokes additional challenges, entailing more complicated delivery strategies. Nose-to-brain (N2B) delivery or the intranasal (IN) administration route provides a less invasive alternative. With the wealth of knowledge available on N2B delivery of nanomedicines and biotherapeutics, there is an opportunity to synthesize the current literature, especially in terms of promising strategies to improve N2B delivery of nanomedicines, highlighting experimental evaluation and translational challenges. We also emphasized the latest advancements in experimental models for nasal delivery. Aiming to bridge the gap between bench research and clinical application, we reviewed the cases of insulin and oxytocin, two biotherapeutics with high clinical potential for CNS-related diseases, and explore how nanomedicine-based platforms can enhance their effectiveness. This review offers a roadmap for overcoming barriers and accelerating the clinical translation of N2B therapeutics. Paraiso, West Kristian; Palacín Ramos, Carlos; Hossain, Parisa Mishal[et al.]. Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery. Nanoscale. 2026, 18, páginas 66-89. Disponible en <https://pubs.rsc.org/en/content/articlelanding/2026/nr/d5nr02259b>. Fecha de acceso: 15 ene. 2026. DOI: 10.1039/d5nr02259b 2040-3372 http://hdl.handle.net/20.500.12328/5174 https://dx.doi.org/10.1039/d5nr02259b Nanomedicine Nanomedicina Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery