2026-04-18T01:32:57Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12328/51332025-11-08T13:32:17Zcom_2072_67741col_2072_484352
RECERCAT
author
Ragucci, Gian Maria
author
Fernández Augè, Antonio
author
Tresserra-Parra, Anna
author
Elnayef, Basel
author
Hernandez Alfaro, Federico
2025-11-08T13:32:17Z
2025-11-08T13:32:17Z
2025-08-22
Ragucci, Gian Maria; Fernández Augè, Antonio; Tresserra Parra, Anna[et al.]. Comparison between CAD/CAM titanium mesh vs. conventional titanium mesh in bone regeneration: a systematic review and metaanalysis. International Journal of Implant Dentistry, 2025, 11(1), 55. Disponible en <https://pubmed.ncbi.nlm.nih.gov/40844656/>. Fecha de acceso: 6 nov. 2025. DOI: 10.1186/s40729-025-00643-5
2198-4034
http://hdl.handle.net/20.500.12328/5133
https://dx.doi.org/10.1186/s40729-025-00643-5
Background Vertical bone defects remain a challenge in implant dentistry. Titanium mesh (TM) is widely used in
guided bone regeneration due to its ability to stabilize grafts, but it requires intraoperative adaptation, increasing
surgical time and the risk of complications like mesh exposure. Customized titanium mesh (CTM), designed using
CAD/CAM or 3D printing, offers a precise fit and may reduce surgical risks. This systematic review and metaanalysis aims to compare CTM and TM in terms of bone gain and complication rates in vertical ridge augmentation
procedures.
Materials and methods A systematic search was carried out in four electronic databases (PubMed, Cochrane
Central, Web of Science, and Google Scholar) up to January 2025, with no time restrictions applied. Studies
comparing customized titanium mesh (CTM) and conventional titanium mesh (TM) for vertical ridge augmentation
were considered eligible if they included at least 10 patients and a minimum follow-up period of 6 months. The
primary outcomes were vertical and horizontal bone gain, as well as membrane exposure. Meta-analyses and metaregressions were performed using R software.
Results A total of 22 studies were included in the analysis (3 randomized controlled trials, 6 prospective studies, 12
retrospective studies, and 1 cohort study), comprising 608 patients and 1,318 implants. The mean vertical bone gain
was 6.24 mm for the TM group and 5.14 mm for the CTM group, with no statistically significant difference between
them (P=0.628). In contrast, CTM achieved significantly greater horizontal bone gain (6.38 mm vs. 3.85 mm; P=0.004).
Membrane exposure occurred more frequently in the TM group (30.9%) than in the CTM group (20.3%), although the
difference was not statistically significant (P=0.721). Other complications, such as infections, were also more common
in the TM group but did not show statistical significance.
Conclusion Within the limitations of the included studies, CTM appears to offer comparable bone gain to TM, with
superior horizontal bone gain and a tendency to fewer complications. The results support the potential advantages of customized mesh in clinical practice. Further randomized trials with standardized protocols and long-term follow-up
are recommended to confirm these findings.
eng
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Titanium mesh
CAD/CAM titanium mesh
Guided bone regeneration
Vertical bone augmentation
Malla de titanio
Malla de titanio CAD/CAM
Regeneración ósea dirigida
Aumento óseo vertical
Malla de titani
Malla de titani CAD/CAM
Regeneració òssia dirigida
Augment ossi vertical
Comparison between CAD/CAM titanium mesh vs. conventional titanium mesh in bone regeneration: a systematic review and meta-analysis
info:eu-repo/semantics/article