2026-04-13T04:13:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12328/35752025-05-16T12:55:00Zcom_2072_67741col_2072_484352

00925njm 22002777a 4500 dc Rappe, Katrin Steffanie author Ortiz, Monica author Punset fuste, Miquel author Molmeneu, Meritxell author Barba, Albert author Mas-Moruno, Carlos author Guillem-Marti, Jordi author Caparrós, Cristina author Ruperez, Elisa author Calero, José author Manzanares Céspedes, Maria Cristina author Gil, FJ author Franch, Jordi author 2022 A lack of primary stability and osteointegration in metallic implants may result in implant loosening and failure. Adding porosity to metallic implants reduces the stress shielding effect and improves implant performance, allowing the surrounding bone tissue to grow into the scaffold. However, a bioactive surface is needed to stimulate implant osteointegration and improve mechanical stability. In this study, porous titanium implants were produced via powder sintering to create different porous diameters and open interconnectivity. Two strategies were used to generate a bioactive surface on the metallic foams: (1) an inorganic alkali thermochemical treatment, (2) grafting a cell adhesive tripeptide (RGD). RGD peptides exhibit an affinity for integrins expressed by osteoblasts, and have been reported to improve osteoblast adhesion, whereas the thermochemical treatment is known to improve titanium implant osseointegration upon implantation. Bioactivated scaffolds and control samples were implanted into the tibiae of rabbits to analyze the effect of these two strategies in vivo regarding bone tissue regeneration through interconnected porosity. Histomorphometric evaluation was performed at 4 and 12 weeks after implantation. Bone-to-implant contact (BIC) and bone in-growth and on-growth were evaluated in different regions of interest (ROIs) inside and outside the implant. The results of this study show that after a long-term postoperative period, the RGD-coated samples presented higher quantification values of quantified newly formed bone tissue in the implant’s outer area. However, the total analyzed bone in-growth was observed to be slightly greater in the scaffolds treated with alkali thermochemical treatment. These results suggest that both strategies contribute to enhancing porous metallic implant stability and osteointegration, and a combination of both strategies might be worth pursuing. Rappe, Katrin Steffanie; Ortiz, Monica; Punset Fuste, Miquel [et al.]. On-growth and In-growth osseointegration enhancement in PM porous Ti-scaffolds by two different bioactivation strategies: alkali thermochemical treatment and RGD Ppeptide coating. International Journal of Molecular Sciences, 2022, 23(3), 1750. Disponible en: <https://www.mdpi.com/1422-0067/23/3/1750>. Fecha de acceso: 24 feb. 2023. DOI: 10.3390/ijms23031750 1422-0067 http://hdl.handle.net/20.500.12328/3575 https://dx.doi.org/10.3390/ijms23031750 Escumes de titani Osteointegració Tractament termoquímic Pèptid RGD En viu implantació Avaluació histomorfomètrica Creixement ossi Espumas de titanio Osteointegración Tratamiento termoquímico Péptido RGD En vivo implantación Evaluación histomorfométrica Crecimiento óseo Titanium foams Osseointegration Thermochemical treatment RGD peptide In vivo implantation Histomorphometric evaluation Bone on-growth On-growth and In-growth osseointegration enhancement in PM porous Ti-scaffolds by two different bioactivation strategies: alkali thermochemical treatment and RGD Ppeptide coating