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oai:recercat.cat:20.500.12328/35362025-05-16T12:47:15Zcom_2072_67741col_2072_484352

2025-05-16T12:47:15Z urn:hdl:20.500.12328/3536 Significance of barrier membrane on the reconstructive therapy of peri-implantitis: a randomized controlled trial Monje, Alberto Pons, Ramón Vilarrasa, Javi Nart, José Wang, Hom-Lay Materials biocompatibles Implants dentals Mandíbula Periimplantitis Regeneració Cicatrització de ferides Materiales biocompatibles Implantes dentales Mandíbula Periimplantitis Regeneración Cicatrización de heridas Biocompatible materials Dental implants Jaw Peri-implantitis Regeneration Wound healing Background: he objective of this trial was to investigate the clinical and radiographic significance of using a mixture of mineralized and demineralized allografts in combination (M) or not (NM) with a resorbable cross-linked barrier membrane in the reconstructive therapy of peri-implantitis defects. Methods: A two-arm randomized clinical trial was performed in patients diagnosed with peri-implantitis that exhibited contained defects. Clinical parameters were recorded at baseline (T0), 6 months (T1), and 12 months (T2). Radiographic parameters were recorded at T0 and T2. A composite criterion for disease resolution was defined a priori. A generalized linear model of repeated measures with generalized estimation equation statistical methods was used. Results: Overall, 33 patients (nimplants = 48) completed the study. At T2, mean disease resolution was 77.1%. The use of a barrier membrane did not enhance the probability of disease resolution at T2 (odds ratio [OR] = 1.55, p = 0.737). Conversely, the odds of disease resolution were statistically associated with the modified plaque index recorded at T0 (OR = 0.13, p = 0.006) and keratinized mucosa width (OR = 2.10, p = 0.035). Moreover, women exhibited greater odds to show disease resolution (OR = 5.56, p = 0.02). Conclusion: Reconstructive therapy by means of a mixture of mineralized and demineralized allografts is effective in clinically resolving peri-implantitis and in gaining radiographic marginal bone level. The addition of a barrier membrane to reconstructive therapy of peri-implantitis does not seem to enhance the outcomes of contained bone defects (NCT05282667). 2025-05-16T12:47:15Z 2025-05-16T12:47:15Z 2022 info:eu-repo/semantics/article Monje, Alberto; Pons, Ramón; Vilarrasa, Javi [et al.]. Significance of barrier membrane on the reconstructive therapy of peri-implantitis: a randomized controlled trial. Journal of Periodontology, 2022, p. 1-13. Disponible en: <https://aap.onlinelibrary.wiley.com/doi/10.1002/JPER.22-0511>. Fecha de acceso: 17 ene. 2023. DOI: 10.1002/JPER.22-0511 1943-3670 http://hdl.handle.net/20.500.12328/3536 https://dx.doi.org/10.1002/JPER.22-0511 eng Journal of Periodontology https://aap.onlinelibrary.wiley.com/doi/10.1002/JPER.22-0511 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess © 2022 The Authors.Journal of Periodontologypublished by Wiley Periodicals LLC on behalf of American Academy of Periodontology. Wiley