2026-04-18T00:30:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12328/35122025-05-16T12:59:36Zcom_2072_67741col_2072_484352

00925njm 22002777a 4500 dc Mele-Casas, Maria author Launes, Cristian author F. de Sevilla, Mariona author Hernandez-Garcia, Maria author Pons-Tomas, Gemma author Bassat, Quique author Fumado, Victoria author Fortuny, Claudia author Garcia-Miquel, Aleix author Bonet-Carne, Elisenda author Prats, Clara author Ajanovic, Sara author Cubells, Marta author Claverol, Joana author Penela-Sanchez, Daniel author Jou, Cristina author Arias, Sara author Balanza, Nuria author Baro, Barbara author Millat-Martinez, Pere author Alonso, Sergio author Alvarez-Lacalle, Enric author Catala, Marti author Cuadras, Daniel author Muñoz-Almagro, Carmen author Gratacos, Eduard author Jordan, Iolanda author Garcia-Garcia, Juan Jose author 2022 Background: Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households. Methods: A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated. Results: 1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01). Conclusions: Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility. Mele-Casas, Maria; Launes, Cristian; F. de Sevilla, Mariona [et al.]. Low transmission of SARS-CoV-2 derived from children in family clusters: an observational study of family households in the Barcelona Metropolitan Area, Spain. PLoS One, 2022, 17(11), e0277754. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277754>. Fecha de acceso: 12 dic. 2022. DOI: 10.1371/journal.pone.0277754 1932-6203 http://hdl.handle.net/20.500.12328/3512 Infeccions pediàtriques SARS-CoV-2 Pediatria Reacció en cadena transcriptasa-polimerasa inversa Serologia Famílies humanes Escoles Prova de virus Infecciones pediátricas SARS-CoV-2 Pediatría Reacción en cadena de la transcriptasa inversa-polimerasa Serología Familias humanas Escuelas Pruebas de virus Pediatric infections SARS CoV 2 Pediatrics Reverse transcriptase-polymerase chain reaction Serology Human families Schools Virus testing Low transmission of SARS-CoV-2 derived from children in family clusters: an observational study of family households in the Barcelona Metropolitan Area, Spain