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00925njm 22002777a 4500 dc Godoy Gallardo, Maria author Eckhard, Ulrich author Delgado, Luis M. author de Roo Puente, Yolanda J.D. author Hoyos Nogués, Mireia author Gil Mur, Francisco Javier author Pérez Antoñanzas, Roman author 2021-12 Bacterial infection of implanted scaffolds may have fatal consequences and, in combination with the emergence of multidrug bacterial resistance, the development of advanced antibacterial biomaterials and constructs is of great interest. Since decades ago, metals and their ions had been used to minimize bacterial infection risk and, more recently, metal-based nanomaterials, with improved antimicrobial properties, have been advocated as a novel and tunable alternative. A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria. Antibacterial mechanisms such as oxidative stress induction, ion release and disruption of biomolecules are currently well accepted. However, the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood. The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing, and allow to mitigate potential side effects to the host. Starting with a general overview of antibacterial mechanisms, we subsequently focus on specific metal ions such as silver, zinc, copper, iron and gold, and outline their distinct modes of action. Finally, we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. Godoy-Gallardo, Maria; Eckhard, Ulrich; Delgado, Luis M. [et al.]. Antibacterial approaches in tissue engineering using metal ions and nanoparticles: from mechanisms to applications. Bioactive Materials, 2021, 6(12), p. 4470-4490. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X21002024>. Fecha de acceso: 28 may. 2021. DOI: 10.1016/j.bioactmat.2021.04.033 2452-199X http://hdl.handle.net/20.500.12328/2568 https://dx.doi.org/10.1016/j.bioactmat.2021.04.033 Malalties bacterianes Resistència als medicaments Materials biomèdics Bacteris Ions Biomolècules Teixits Regeneració (Biologia) Ions metàl·lics Nanopartícules Enfermedades bacterianas Resistencia a los medicamentos Materiales biomédicos Bacterias Iones Biomoléculas Tejidos Regeneración (Biología) Iones metálicos Nanopartículas Bacterial diseases Drug resistance Biomedical materials Bacteria Ions Biomolecules Tissues Regeneration (Biology) Metal ions Nanoparticles Antibacterial approaches in tissue engineering using metal ions and nanoparticles: from mechanisms to applications