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2025-05-20T00:01:21Z urn:hdl:20.500.12328/1607 Evaluation of bone loss in antibacterial coated dental implants: an experimental study in dogs Godoy Gallardo, Maria Manzanares-Céspedes, Maria Cristina Sevilla Sánchez, Pablo Nart Molina, José Manzanares, Norberto Manero Planella, José María Gil Mur, Francisco Javier Boyd, Steven K. Rodríguez, Daniel Implants dentals Gossos Bacteris Implantes dentales Perros Bacterias Dental implants Dogs Bacteria The aim of this study was to evaluate the in vivo effect of antibacterial modified dental implants in the first stages of peri-implantitis. Thirty dental implants were inserted in the mandibular premolar sites of 5 beagle dogs. Sites were randomly assigned to Ti (untreated implants, 10 units), Ti_Ag (silver electrodeposition treatment, 10 units), and Ti_TSP (silanization treatment, 10 units). Coated implants were characterized by scanning electron microscopy, interferometry and X-ray photoelectron spectroscopy. Two months after implant insertion, experimental peri-implantitis was initiated by ligature placement. Ligatures were removed 2 months later, and plaque formation was allowed for 2 additional months. Clinical and radiographic analyses were performed during the study. Implant-tissue samples were prepared for micro computed tomography, backscattered scanning electron microscopy, histomorphometric and histological analyses and ion release measurements. X-ray, SEM and histology images showed that vertical bone resorption in treated implants was lower than in the control group (P < 0.05). This effect is likely due to the capacity of the treatments to reduce bacteria colonization on the implant surface. Histological analysis suggested an increase of peri-implant bone formation on silanized implants. However, the short post-ligature period was not enough to detect differences in clinical parameters among implant groups. Within the limits of this study, antibacterial surface treatments have a positive effect against bone resorption induced by peri-implantitis. 2025-05-20T00:01:21Z 2025-05-20T00:01:21Z 2016-12 info:eu-repo/semantics/article Godoy-Gallardo, Maria; Manzanares-Céspedes, Maria Cristina; Sevilla, Pablo [et al.]. Evaluation of bone loss in antibacterial coated dental implants: an experimental study in dogs. Materials Science and Engineering: C, 2016, 69, p. 538-545. Disponible en: <https://www.sciencedirect.com/science/article/abs/pii/S0928493116306944?via%3Dihub>. Fecha de acceso: 28 jun. 2020. DOI: 10.1016/j.msec.2016.07.020 0928-4931 http://hdl.handle.net/20.500.12328/1607 https://dx.doi.org/10.1016/j.msec.2016.07.020 eng Materials Science and Engineering: C 69; info:eu-repo/grantAgreement/ES/1PE/MAT2009-12547 info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706 © 2016 Elsevier B.V. All rights reserved. Elsevier