2026-04-14T05:25:50Zhttps://recercat.cat/oai/request
oai:recercat.cat:20.500.12328/15992025-05-20T00:03:29Zcom_2072_67741col_2072_484352
RECERCAT author Rodríguez-Rodríguez, Rosalía author Herrera, María Dolores author De Sotomayor, Maria Alvarez author Ruiz-Gutiérrez, Valentina 2025-05-20T00:03:29Z 2025-05-20T00:03:29Z 2009-11 Rodriguez-Rodriguez, Rosalia; Herrera, Maria Dolores; De Sotomayor, Maria Alvarez [et al.]. Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats. British Journal of Nutrition, 2009, 102, p. 1435–1444. Disponible en: <https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-pomace-olive-oilenriched-diets-on-endothelial-function-of-small-mesenteric-arteries-from-spontaneously-hypertensive-rats/7517AE78046D6ED3503F6E414AB78F1B<. Fecha de acceso: 23 jun. 2020. DOI: 10.1017/S0007114509990754 0007-1145 http://hdl.handle.net/20.500.12328/1599 https://dx.doi.org/10.1017/S0007114509990754 Pomace olive oil (POM), an olive oil subproduct traditionally used in Spain, is a good source of minor components from the unsaponifiable fraction such as triterpenoids, mainly in the form of oleanolic acid, which induces vascular protection and vasodilatation. Our aim was to evaluate the effects of long-term intake of diets enriched in POM with high concentration in oleanolic acid on endothelial dysfunction associated to hypertension in small mesenteric arteries (SMA) from spontaneously hypertensive rats (SHR). During 12 weeks, rats (six rats per group) were fed either a control 2 % maize oil diet (BD), or high-fat diets containing 15 % refined olive oil (OL), pomace olive oil (POM), or pomace olive oil supplemented in oleanolic acid (POMO; up to 800 parts per million). Endothelial and vascular functions were assessed by relaxing or contracting responses to acetylcholine (ACh) or phenylephrine, respectively. The involvement of endothelium-derived relaxing factors in these responses was evaluated. In contrast to BD, SHR fed high-fat diets showed a biphasic response to ACh related to changes in eicosanoid metabolism. POM enhanced the endothelial function in SMA from SHR by increasing the endothelium-derived hyperpolarising factor (EDHF)-type component, whereas administration of POMO resulted in a similar contribution of NO/EDHF in the endothelial response to ACh. The present study shows that despite the lack of changes in blood pressure, consumption of POM improves endothelial function in SMA from SHR by improving the agonist-mediated EDHF/NO response. Thus, triterpenoids confer a protective role to POM against endothelial dysfunction in hypertension. eng © The Authors 2009 Oli d'oliva Endoteli Hipertensió Artèries Aceite de oliva Endotelio Hipertensión Arterias Olive oil Endothelium Hypertension Arteries Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats info:eu-repo/semantics/article