2026-04-17T16:21:16Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12328/14052025-05-20T00:03:52Zcom_2072_67741col_2072_484352
RECERCAT
author
Fernandez, Rafael
author
Cano Hernandez, Silvia
author
Catalan, Ignacio
author
Rubio Sanchiz, Olga
author
Subirà Cuyàs, Carles
author
Masclans, Jaume
author
Rognoni, Gina
author
Ventura, Lara
author
Macharete, Caroline
author
Winfield, Len
author
Alcoverro, Josep Mª.
2025-05-20T00:03:52Z
2025-05-20T00:03:52Z
2018-11-16
Fernandez, Rafael; Cano, Silvia; Catalan, Ignacio [et al.]. High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study. Journal of Intensive Care, 2018, vol. 6, p. 1-7. Disponible en: <https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-018-0343-3#Ack1>. Fecha de acceso: 22 dic. 2019. DOI: 10.1186/s40560-018-0343-3.
2052-0492
http://hdl.handle.net/20.500.12328/1405
https://dx.doi.org/10.1186/s40560-018-0343-3
Background: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ICU discharge. We aimed to determine RDW’s association with survival after ICU discharge and whether RDW can improve the accuracy of the SS. Design: Retrospective cohort study. Setting: general ICU at a university hospital. Patients: We included all patients discharged to wards from January 2010 to October 2016. Methods: We analyzed associations between RDW and variables recorded on admission (age, comorbidities, severity score), during the ICU stay (treatments, complications, length of stay (LOS)), and at ICU discharge (SS). The primary outcome was hospital mortality. Statistical analysis included multivariable logistic regression and receiver operating characteristic curve (ROC) analyses. Results: We discharged 3366 patients to wards; median ward LOS was 7 [4–13] days; ward mortality was 5.2%. Mean RDW at ICU discharge was 15.4 ± 2.5%. Ward mortality was higher at each quartile of RDW (0.7%, 2.9%, 7.5%, 10.3%; area under ROC 0.81). A logistic regression model with Sabadell score obtained an excellent accuracy for ward mortality (area under ROC 0.863), and the addition of RDW slightly improved accuracy (AUROC 0.890, p < 0.05). Recursive partitioning demonstrated higher mortality in patients with high RDW at each SS level (1.6% vs. 0.3% in SS0, 9.7% vs. 1.1% in SS1, 21.9% vs. 9.7% in SS2), but not in SS3. Conclusion: High RDW is a marker of severity at ICU discharge and improves the accuracy of Sabadell score in predicting ward mortality except in the more extreme SS3.
eng
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Mortalitat
Marcadors bioquímics
Cèl·lules sanguínies
Mortalidad
Marcadores bioquímicos
Células sanguíneas
Mortality
Biomarkers
Blood cells
High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study
info:eu-repo/semantics/article