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oai:recercat.cat:20.500.12328/14052025-05-20T00:03:52Zcom_2072_67741col_2072_484352

00925njm 22002777a 4500 dc Fernandez, Rafael author Cano Hernandez, Silvia author Catalan, Ignacio author Rubio Sanchiz, Olga author Subirà Cuyàs, Carles author Masclans, Jaume author Rognoni, Gina author Ventura, Lara author Macharete, Caroline author Winfield, Len author Alcoverro, Josep Mª. author 2018-11-16 Background: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ICU discharge. We aimed to determine RDW’s association with survival after ICU discharge and whether RDW can improve the accuracy of the SS. Design: Retrospective cohort study. Setting: general ICU at a university hospital. Patients: We included all patients discharged to wards from January 2010 to October 2016. Methods: We analyzed associations between RDW and variables recorded on admission (age, comorbidities, severity score), during the ICU stay (treatments, complications, length of stay (LOS)), and at ICU discharge (SS). The primary outcome was hospital mortality. Statistical analysis included multivariable logistic regression and receiver operating characteristic curve (ROC) analyses. Results: We discharged 3366 patients to wards; median ward LOS was 7 [4–13] days; ward mortality was 5.2%. Mean RDW at ICU discharge was 15.4 ± 2.5%. Ward mortality was higher at each quartile of RDW (0.7%, 2.9%, 7.5%, 10.3%; area under ROC 0.81). A logistic regression model with Sabadell score obtained an excellent accuracy for ward mortality (area under ROC 0.863), and the addition of RDW slightly improved accuracy (AUROC 0.890, p < 0.05). Recursive partitioning demonstrated higher mortality in patients with high RDW at each SS level (1.6% vs. 0.3% in SS0, 9.7% vs. 1.1% in SS1, 21.9% vs. 9.7% in SS2), but not in SS3. Conclusion: High RDW is a marker of severity at ICU discharge and improves the accuracy of Sabadell score in predicting ward mortality except in the more extreme SS3. Fernandez, Rafael; Cano, Silvia; Catalan, Ignacio [et al.]. High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study. Journal of Intensive Care, 2018, vol. 6, p. 1-7. Disponible en: <https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-018-0343-3#Ack1>. Fecha de acceso: 22 dic. 2019. DOI: 10.1186/s40560-018-0343-3. 2052-0492 http://hdl.handle.net/20.500.12328/1405 https://dx.doi.org/10.1186/s40560-018-0343-3 Mortalitat Marcadors bioquímics Cèl·lules sanguínies Mortalidad Marcadores bioquímicos Células sanguíneas Mortality Biomarkers Blood cells High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study