2026-04-17T03:49:24Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/8752025-10-22T11:09:58Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Gifre-Renom, L.
author
Carratalá, J. V.
author
Parés, S.
author
Sánchez-García, L.
author
Ferrer-Miralles, N.
author
Villaverde, A.
author
Bach, A.
author
Garcia-Fruitos, Elena
author
Alomar, Oscar
other
Producció Animal
group
Producció de Remugants
2025-10-22T11:09:58Z
2025-10-22T11:09:58Z
2020-07-09
Gifre-Renom, L., J. V. Carratalá, S. Parés, L. Sánchez-García, N. Ferrer-Miralles, A. Villaverde, A. Bach, Elena Garcia-Fruitós, and Anna Arís. 2020. "Potential Of MMP-9 Based Nanoparticles At Optimizing The Cow Dry Period: Pulling Apart The Effects Of MMP-9 And Nanoparticles". Scientific Reports 10 (1). doi:10.1038/s41598-020-67176-2.
2045-2322
http://hdl.handle.net/20.500.12327/875
https://doi.org/10.1038/s41598-020-67176-2
The cow dry period is a non-milking interval where the mammary gland involutes and regenerates
to guarantee an optimal milk production in the subsequent lactation. Important bottlenecks such
as the high risk of intramammary infections complicate the process. Antibiotics have been routinely
used as a preventive treatment but the concerns about potential antibiotic resistance open a new
scenario in which alternative strategies have to be developed. Matrix metalloproteinase-9 (MMP-9) is
an enzyme able to degrade the extracellular matrix, triggering the involution and immune function of
cow mammary gland. We have studied the infusion into the mammary gland of MMP-9 inclusion bodies
as protein-based nanoparticles, demonstrating that 1.2 mg of MMP-9 enhanced the involution and
immune function of the cow mammary gland. However, the comparison of the efects triggered by the
administration of an active and an inactive form of MMP-9 led to conclude that the response observed
in the bovine mammary gland was mainly due to the protein format but not to the biological activity of
the MMP-9 embedded in the inclusion body. This study provides relevant information on the future use
of protein inclusion bodies in cow mammary gland and the role of MMP-9 at dry-of.
eng
Attribution 4.0 International
Potential of MMP-9 based nanoparticles at optimizing the cow dry period: pulling apart the effects of MMP-9 and nanoparticles
info:eu-repo/semantics/article