2026-04-17T02:02:49Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/802025-10-22T11:18:53Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Correa-Fiz, Florencia
author
Franzo, Giovanni
author
Llorens, Anna
author
Segalés, Joaquim
author
Kekarainen, Tuija
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:18:53Z
2025-10-22T11:18:53Z
2018-10-19
Correa-Fiz, Florencia, Giovanni Franzo, Anna Llorens, Joaquim Segalés, and Tuija Kekarainen. 2018. "Porcine Circovirus 2 (PCV-2) Genetic Variability Under Natural Infection Scenario Reveals A Complex Network Of Viral Quasispecies". Scientific Reports 8 (1). Springer Nature. doi:10.1038/s41598-018-33849-2.
2045-2322
http://hdl.handle.net/20.500.12327/80
https://doi.org/10.1038/s41598-018-33849-2
Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential
emergence of diferent genotypes and strains. Despite the likely relevance in the emergence of new
PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short
transmission chains are still largely unknown. This study aimed to analyze the within-host genetic
variability of PCV-2 subpopulations to unravel the forces driving PCV-2 evolution. A longitudinal weekly
sampling was conducted on individual animals located in three farms after the frst PCV-2 detection. The
analysis of polymorphisms evaluated throughout the full PCV-2 genome demonstrated the presence
of several single nucleotide polymorphisms (SNPs) especially in the genome region encoding for the
capsid gene. The global haplotype reconstruction allowed inferring the virus transmission network
over time, suggesting a relevant within-farm circulation. Evidences of co-infection and recombination
involving multiple PCV-2 genotypes were found after mixing with pigs originating from other sources.
The present study demonstrates the remarkable within-host genetic variability of PCV-2 quasispecies,
suggesting the role of the natural selection induced by the host immune response in driving PCV-2
evolution. Moreover, the efect of pig management in multiple genotype coinfections occurrence and
recombination likelihood was demonstrated.
eng
Attribution 4.0 International
Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies
info:eu-repo/semantics/article