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00925njm 22002777a 4500 dc Nordi, Wiolene M. author Marti, Sonia author Gellatlya, Désirée author Meléndez, Daniela M. author González, Luciano A. author McAllister, Tim A. author Fierheller, Erin E. author Caulkett, Nigel A. author Janzen, Eugene author Schwartzkopf-Genswein, Karen S. author 2019-10-19 One hundred and seventy-four Angus bull calves (248 ± 27.1 kg of body weight (BW), 6-mo-old) were used in a 71 d study to assess the efficacy of the combination of flunixin meglumine and lidocaine in mitigating pain associated with band and knife castration. The experiment consisted of a 3 × 2 factorial design that included castration method -sham (C), band (B) or knife (K); and medication – lidocaine (scrotal ring block 30 mL, 2% HCl lidocaine) and flunixin meglumine (single s.c. dose of 2.2 mg/kg BW) (M), or saline solution (NM). Animals were weighed on d 0 and weekly until d 71 (final BW) post-castration to obtain ADG. Physiological indicators included salivary cortisol collected on d 0 (30, 60, 120 and 240 min), d 2, 8, and weekly until d 48 post-castration; scrotal and eye temperature assessed on d 1, 2, 6, 8, and weekly until d 36 post-castration; fecal samples for E. coli collected on d 0, 2, 6, 8, and 22 post-castration. Behavioral measures included stride length on d 0, 8, and weekly until d 36, visual analog scale (VAS) evaluated during castration, and feeding behavior collected daily from d 0 to d 71 post-castration. Final BW and ADG were greater (P < 0.05) in C than B and K castrated calves. Salivary cortisol concentrations were greater (P < 0.05) in B and K calves than C calves up to 4-h post-castration, and remained greater in K calves up to 48-h post-castration, while concentrations were lower (P = 0.01) in M than NM calves. Fecal E. coli varied daily (P = 0.01) however, there was no obvious pattern over time. Scrotal temperature was greatest (P < 0.05) in K, intermediate in C and lowest in B calves, except at 30 min, and 22 and 36 d post-castration where they did not differ from C calves. Eye temperature was greater (P < 0.05) in B and K than C calves on d 2 and 8 post-castration. No differences (P > 0.10) were observed for stride length. The VAS scores were greater (P = 0.01) in K than C and B calves, while NM had greater scores (P < 0.01) than M calves. Dry matter intake and meal size were greater (P = 0.05) in M than NM calves. Meal duration was greater (P = 0.01) in B and C than K calves on d 0, while K calves had greater (P < 0.01) meal duration than C calves 1 and 2-wk post-castration. Overall, the combination of flunixin meglumine and lidocaine reduced physiological and behavioral indicators of pain, suggesting that their combined use was effective at mitigating pain associated with band and knife castration. Nordi, Wiolene M., Sonia Marti, Désirée Gellatly, Daniela M. Meléndez, Luciano A. González, Tim A. McAllister, Erin E. Fierheller, Nigel A. Caulkett, Eugene Janzen, and Karen S. Schwartzkopf-Genswein. 2019. "Effect Of Preemptive Flunixin Meglumine And Lidocaine On Behavioral And Physiological Indicators Of Pain Post-Band And Knife Castration In 6-Mo-Old Beef Calves". Livestock Science 230: 103838. Elsevier BV. doi:10.1016/j.livsci.2019.103838. 1871-1413 http://hdl.handle.net/20.500.12327/790 https://doi.org/10.1016/j.livsci.2019.103838 Effect of preemptive flunixin meglumine and lidocaine on behavioral and physiological indicators of pain post-band and knife castration in 6-mo-old beef calves