2026-04-19T11:35:23Zhttps://recercat.cat/oai/request
oai:recercat.cat:20.500.12327/7032025-10-22T11:13:23Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT author Guirado, Pedro author Paytubi, Sonia author Miró, Elisenda author Iglesias-Torrens, Yaidelis author Navarro, Ferran author Cerdà-Cuéllar, Marta author Attolini, Camille Stephan-Otto author Balsalobre, Carlos author Madrid, Cristina other Producció Animal group Sanitat Animal 2025-10-22T11:13:23Z 2025-10-22T11:13:23Z 2020-02-26 Guirado, Pedro, Sonia Paytubi, Elisenda Miró, Yaidelis Iglesias-Torrens, Ferran Navarro, Marta Cerdà-Cuéllar, Camille Stephan-Otto Attolini, Carlos Balsalobre, and Cristina Madrid. 2020. "Differential Distribution Of The Wlan And Cgtb Genes, Associated With Guillain-Barré Syndrome, In Campylobacter Jejuni Isolates From Humans, Broiler Chickens, And Wild Birds". Microorganisms 8 (3): 325. MDPI AG. doi:10.3390/microorganisms8030325. 2076-2607 http://hdl.handle.net/20.500.12327/703 https://doi.org/10.3390/microorganisms8030325 Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtB gene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells. eng Attribution 4.0 International Differential distribution of the wlaN and cgtB genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds info:eu-repo/semantics/article